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opatrnost se doporučuje v případech, kdy se v daném období podávají warfarin, acenokumarol, tolbutamid, fenytoin nebo jiné léčivé látky, o nichž je známo, že jsou biotransformovány cyp2c9.
caution is advised when warfarin, acenocoumarol, tolbutamide, phenytoin or other active substances that are known to be metabolised by cyp2c9 are administered during this time period.
Last Update: 2012-04-11
Usage Frequency: 2
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studie in vivo u člověka a in vitro studie na humánních jaterních mikrozomech prokázaly, že nevirapin je rozsáhle biotransformován oxidativním metabolismem cytochromu p450 na několik hydroxylovaných metabolitů.
in vivo studies in humans and in vitro studies with human liver microsomes have shown that nevirapine is extensively biotransformed via cytochrome p450 (oxidative) metabolism to several hydroxylated metabolites.
Last Update: 2011-10-23
Usage Frequency: 1
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