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demethylering til desmethylclomipramin.
the major route of biotransformation of clomipramine is demethylation to desmethylclomipramine.
Last Update: 2011-10-23
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sker hovedsagligt som en demethylering til desmethylclomipramin.
the major route of biotransformation of clomipramine is demethylation to desmethylclomipramine.
Last Update: 2008-03-04
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biotransformationen af clomipramin sker hovedsagligt som en demethylering til desmethylclomipramin.
the major route of biotransformation of clomipramine is demethylation to desmethylclomipramine.
Last Update: 2017-04-26
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det aktive stof in vivo er clomipramin og dets hovedmetabolit, desmethylclomipramin.
the active components in vivo are clomipramine and its major metabolite, desmethylclomipramine.
Last Update: 2017-04-26
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ved steady state er ratio af plasma clomipramin: desmethylclomipramin koncentrationen ca.
at steady state, the ratio of plasma clomipramine to desmethylclomipramine concentrations is approximately 3:1.
Last Update: 2017-04-26
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maksimalt plasmaniveau af clomipramin og desmethylclomipramin opnås hurtigt (1½-2½ time) .
peak plasma levels of clomipramine and desmethylclomipramine are rapidly reached (approx.1.5-2.5 hours) .
Last Update: 2008-03-04
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clomipramin og dets vigtigste metabolit, desmethylclomipramin, forhindrer en række neurotransmittere i at blive genoptaget i nerveceller i hjernen og rygmarven.
in the body, clomipramine and its major metabolite, desmethylclomipramine prevent some neurotransmitters from being taken back up into nerve cells in the brain and spinal cord.
Last Update: 2012-04-12
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eliminations- t½ efter intravenøs administration af clomipraminhydroklorid hos hund var 6. 4 timer for clomipramin og 3. 6 timer for desmethylclomipramin.
the elimination t1/ 2 after intravenous administration of clomipramine hydrochloride in dogs was 6.4 hours for clomipramine and 3.6 hours for desmethylclomipramine.
Last Update: 2012-04-12
Usage Frequency: 3
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gentagen administration af clomicalm forårsager moderate stigninger i plasmakoncentrationer, akkumuleringsratio efter oral administration to gange daglig var 1.2 for clomipramin og 1.6 for desmethylclomipramin, steady state blev nået indenfor 3 dage.
repeated administration of clomicalm causes moderate increases in plasma concentrations, accumulation ratios after oral administration twice daily were 1.2 for clomipramine and 1.6 for desmethylclomipramine, with steady state being reached within 3 days.
Last Update: 2017-04-26
Usage Frequency: 4
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både clomipramin og desmethylclomipramin bidrager til effekten af clomicalm: clomipramin er en potent og selektiv 5-ht reuptake-hæmmer, medens desmethylclopramin er en potent og selektiv noradrenalin reuptake-hæmmer.
both clomipramine and desmethylclomipramine contribute to the effects of clomicalm: clomipramine is a potent and selective 5-ht reuptake inhibitor while desmethylclomipramine is a potent and selective noradrenaline reuptake inhibitor.
Last Update: 2017-04-26
Usage Frequency: 4
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