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dette medførte dog kun en 2- fold forøgelse af den samlede methylnaltrexoneksponering (auc).
severe renal impairment decreased the renal clearance of methylnaltrexone by 8- to 9-fold; however, this resulted in only a 2-fold increase in total methylnaltrexone exposure (auc).
Last Update: 2011-10-23
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vægt en samlet analyse af farmakokinetiske data fra raske forsøgspersoner viste stigende methylnaltrexoneksponering med dosisjustering i mg/ kg ved stigende kropsvægt.
weight an integrated analysis of pharmacokinetic data from healthy subjects indicated that methylnaltrexone mg/ kg dose-adjusted exposure increased as body weight increased.
Last Update: 2012-04-12
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den gennemsnitlige methylnaltrexoneksponering ved 0, 15 mg/ kg over et vægtområde på 38- 144 kg var 179 ng· t/ ml (område=139 - 240).
the mean methylnaltrexone exposure at 0.15 mg/ kg over a weight range of 38 to 114 kg was 179 (range=139-240) ng. h/ ml.
Last Update: 2012-04-12
Usage Frequency: 2
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