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præsystemisk glukuronidering er omfattende.
presystemic glucuronidation is extensive.
Last Update: 2017-04-26
Usage Frequency: 4
Quality:
zaleplon metaboliseres primært i leveren og undergår signifikant præsystemisk metabolisme.
zaleplon is metabolised primarily by the liver and undergoes significant presystemic metabolism.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
leverinsufficiens zaleplon metaboliseres primært i leveren og undergår signifikant præsystemisk metabolisme.
hepatic impairment zaleplon is metabolised primarily by the liver and undergoes significant presystemic metabolism.
Last Update: 2012-04-12
Usage Frequency: 4
Quality:
zaleplon gennemgår også præsystemisk metabolisme, resulterende i en absolut biotilgængelighed på ca.30%.
zaleplon undergoes presystemic metabolism, resulting in an absolute bioavailability of approximately 30%.
Last Update: 2008-03-04
Usage Frequency: 4
Quality:
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efter oral administration gennemgår mycophenolatmofetil en hurtig og udstrakt absorption og fuldstændig præsystemisk metabolisme til den aktive metabolit, mpa.
following oral administration, mycophenolate mofetil undergoes rapid and extensive absorption and complete presystemic metabolism to the active metabolite, mpa.
Last Update: 2017-04-26
Usage Frequency: 10
Quality:
den lave systemiske tilgængelighed skyldes præsystemisk clearance i gastrointestinal mucosa og/ eller first- pass metabolisme i leveren.
the low systemic availability is attributed to presystemic clearance in gastrointestinal mucosa and/ or hepatic first-pass metabolism
Last Update: 2012-04-12
Usage Frequency: 6
Quality:
den absolutte biotilgængelighed af dronedaron (indgivet med føde) er dog grundet præsystemisk first-pass metabolisme 15 %.
however due to presystemic first pass metabolism, the absolute bioavailability of dronedarone (given with food) is 15%.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
resten af den inhalerede dosis bliver formentlig slugt, men bidrager minimalt til den systemiske påvirkning på grund af lav vandopløselighed og præsystemisk metabolisme, så den perorale biotilgængelighed er under 1%.
the remainder of the inhaled dose may be swallowed but contributes minimally to systemic exposure due to the low aqueous solubility and pre-systemic metabolism, resulting in oral availability of less than 1%.
Last Update: 2012-04-12
Usage Frequency: 6
Quality:
der dannes mindre nap226-90 efter påføring af depotplasteret, formodentlig på grund af manglende præsystemisk (hepatisk first pass) metabolisering i modsætning til oral indgift.
less nap226-90 is formed following application of the transdermal patch, presumably because of the lack of presystemic (hepatic first pass) metabolism, in contrast to oral administration.
Last Update: 2017-04-26
Usage Frequency: 5
Quality:
resten af den inhalerede dosis fluticasonpropionat kan evt. blive slugt, men bidrager minimalt til den systemiske eksponering på grund af lav vandopløselighed og præsystemisk metabolisme, hvilket resulterer i en oral tilgængelighed på under 1 %.
the remainder of the inhaled dose of fluticasone propionate may be swallowed but contributes minimally to systemic exposure due to the low aqueous solubility and presystemic metabolism, resulting in oral availability of less than 1%.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
disse forskelle skyldtes sandsynligvis en lavere præsystemisk metabolisme af anagrelid end af 2- amino- 5, 6 - dichlor- 3, 4- dihydroquinazolin hos ældre patienter.
these differences were likely to be caused by lower presystemic metabolism of anagrelide to 2-amino-5, 6-dichloro-3, 4-dihydroquinazoline in the elderly patients.
Last Update: 2012-04-12
Usage Frequency: 2
Quality: