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met herhaalde toediening en resulterende plasmaconcentratie-accumulatie naderde de eliminatiesnelheid nulde-ordekinetiek.
with repeated administration and consequent plasma concentration accumulation, the rate of elimination approached zero-order kinetics.
== nulde ordereacties ==reacties van nulde orde worden aangetroffen bij ontledingsreacties, waarbij de reactiesnelheid onafhankelijk is van de concentratie van het reagens.
though it was quite popular in the usa since the late nineteenth century, it was banned by the u.s. food and drug administration (fda) in the 1990s due to lack of proof of efficacy.