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transelat1-introduction hepatic fibrosis is a dynamic wound-healing response to chronic hepatic injuries such as alcoholism and viral hepatitis in patients. accumulated evidence suggests that hepatic fibrosis is a reversible process [1]. thioacetamide (taa) is a thiono-sulphur-containing compound, known to be one of the most potent hepatotoxicants in experimental animals.taa-induced hepatic diseases in rat is a good model for determining the anti-inflammatory potential of natural products as it perfectly mimics human chronic hepatic diseases, including viral hepatitis [2] and fibrosis [3]. taa-associated hepatic injury may be caused by ros production and lipid peroxidation [4,5]. gallic acid (3,4,5-trihydroxy benzoic acid, ga) is a natural botanic phenolic compound, which is widely distributed in grapes, green tea, and pomegranate. studies have shown that ga processes a lot of biological activities, such as anti-inflammatory, antimutagenic, antioxidation, and anticancer [6]. ferulic acid (fa) is a phenolic compound, formed during the metabolism of phenylalanine and tyrosine. it occurs primarily in rice, wheat, barely, oat, roasted coffee, tomatoes, vegetables and citrus fruits [7].fa acts as a strong membrane antioxidant in humans and is known to be effective against skin disorders, skin cancer, ageing, fatigue, muscle wasting, cold, flu and influenza [8]. or
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Last Update: 2017-01-23
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