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once in the cell, pemetrexed is rapidly and efficiently converted to polyglutamate forms by the enzyme folylpolyglutamate synthetase.
når pemetrexed er trængt ind i cellen, omdannes det hurtigt til polyglutamatformer via enzymfolylpolyglutamatsyntetase.
due to their effect on renal prostaglandines, prostaglandin synthetase inhibitors like nimesulide may increase the nephrotoxicity of cyclosporines.
som følge af virkningen på nyreprostaglandiner, kan prostaglandin synthetase hæmmere, såsom nimesulide øge cyclosporins nefrotokcisitet.
ammonaps is indicated as adjunctive therapy in the chronic management of urea cycle disorders, involving deficiencies of carbamylphosphate synthetase, ornithine transcarbamylase or argininosuccinate synthetase.
ammonaps er indiceret som adjuvant behandling til den kroniske kontrol af urinstofcyklusdefekter, som involverer mangel på carbamylphosphatsyntetase, ornithintranscarbamylase eller argininosuccinatsyntetase.
carglumic acid was shown to decrease blood ammonia levels and increase urea levels in blood and urine, whereas the liver content of carbamoyl phosphate synthetase activators was significantly increased.
cargluminsyre viste sig at nedsætte ammoniumniveauerne i blodet og øge ureaniveauerne i blod og urin, medens leverens indhold af carbamoylfosfatsyntetaseaktivatorer var signifikant øgede.
carglumic acid is a structural analogue of n-acetylglutamate, which is the naturally occurring activator of carbamoyl phosphate synthetase, the first enzyme of the urea cycle.
cargluminsyre er en strukturel analog til n-acetylglutamat, som er den naturligt forekommende aktivator af carbamoylfosfatsyntetase, det første enzym i ureacyklussen.
after a single dose, intracellular and serum activity of 2-5a synthetase and serum concentrations of beta-2 microglobulin and neopterin increase within 24 hours, and start to decline within 2 days.
efter en enkel dosis stiger både den intracellulære og serum aktiviteten af 2-5a synthetase og serum koncentrationen af beta2-mikroglobulin og neopterin inden for 24 timer og begynder at aftage inden for 2 dage.
citrulline or arginine supplementation is required for patients diagnosed with neonatal-onset form of carbamyl phosphate synthetase or ornithine transcarbamylase deficiency at a dose of 0.17 g/kg/day or 3.8 g/m2/day.
citrullin- eller arginintilskud er nødvendigt til patienter, som har fået diagnosticeret neonatalt indsættende mangel på carbamylphosphatsyntetase eller ornithintranscarbamylase med en dosering på 0,17 g/kg/dag eller 3,8 g/m2/dag.