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google Zaleplon is a hypnotic which is drug that has the ability to cause sleep. It is indicated for use in patients that have difficulty falling asleep and is not indented to treat those who have difficulty staying asleep or who wake too early. It is different in chemical structure from benzodiazepines but acts at the same receptors in the brain as benzodiazepines. While benzodiazepines are used primarily in the treatment of anxiety, zaleplon and similar drugs are used almost exclusively for the treatment of insomnia.
In the United States and many other countries, Zaleplon is marketed as Sonata by King Pharmaceuticals. In Canada, zaleplon was sold under the brand name Starnoc however it was taken from the market; the reasons for this discontinuation are not clear. Zaleplon is available in some countries as Hegon, Zalep, Zaplon, or Zerene. The patent on Sonata began to expire on June 6, 2008 and King Pharmaceuticals does not have exclusivity as listed in the FDA’s Orange Book. More on zaleplon.
Sonata is available in 5 mg and 10 mg dosages; however, physicians sometimes prescribe a 20 mg treatment (two 10 mg capsules). Clinical safety studies were conducted using doses as high as 60 mg. Zaleplon is indicated for short term treatment of insomnia, that is, insomnia that is corrected by seven to ten days of treatment. The FDA has approved use of zaleplon for up to 30 days. Zaleplon is known to cause CNS depression and its affects are relatively rapid. Zaleplon causes sedation and sleep within one hour of administration therefore it should only be taken before bed and never before any activity that requires alertness. Like benzodiazepines, alcohol use can potentiate the CNS depressant effects and alcohol should not be consumed while taking zaleplon. Of note, zaleplon is potentially habit forming and dependency may occur. Once the drug is discontinued, one may experience rebound insomnia simply because the medicine has been taken away. Because of its sedative and euphoric effects, zaleplon may be abused i.e. used for non-medical, illegal reasons. NIH Information on Zaleplon
Zolpidem is sedative-hypnotic medicine that is used to treat short-term insomnia. Its chemical structure is different than benzodiazepines but exerts its sedative affect by acting on so-called benzodiazepine receptors in the brain. Zolpidem does not have the same disruptive effects on sleep as benzodiazepines.
Zolpidem is marketed in the United States as Ambien but is known commercially by many other names worldwide. (The Guardian reports that 5.3 million people in England alone take zolpidem.) Ambien is available as 5 mg and 10 mg tablets and the maximum and usual treatment dose is 10 mg. This medication should not be taken with alcohol as excessive CNS depression can occur. There is also a potential for dependence and abuse with zolpidem. The most common side effects were headache, sleepiness and dizziness. A less common side effect is the "zombie" effect - unusual behavior while asleep.
Ambien is sold by Sanofi Aventis although at least 13 companies manufacture and sell a generic version of the rapid-acting form of zolpidem. Sanofi Aventis has extended the commercial viability of this drug by patenting and selling a CR or Controlled Release formulation. The CR formulation combines both a rapid-acting form and a slow-release form in a layered pill. According to the manufacturers, this allows a person suffering from insomnia to achieve sleep, from the rapid-acting component, and stay asleep, from the slow-acting component. Importantly, the chemical structure of the drug is the same in both the fast and slow layers, however the slow release layer contains a proprietary mixture of inactive ingredients that delays absorption and prolongs the hypnotic effect. Ambien CR is available in 6.25 and 12.5 mg strengths. NIH Information on Zolpidem.
Triazolam is related in structure to benzodiazepines but is of a slightly different class than classic benzodiazepines such as Ativan and Valium. Despite this subtle structural difference, triazolam achieves its biological effect by acting at benzodiazepine receptors in various regions of brain. Triazolam is indicated for the short term treatment of insomnia and should not be used for longer than three consecutive weeks. In clinical studies, triazolam was able to decrease sleep latency (you get to sleep faster), increase the duration of sleep and decrease the number of times people with insomnia wake during the night.
Triazolam was originally branded as Halcion; however there is no longer patent protection or exclusivity on this brand. It is still manufactured and sold as Halcion by Pharmacia and Upjohn yet generic versions exist. Triazolam is available in 0.125 and 0.25 mg tablets and a single dose of either strength is usually sufficient for uncomplicated insomnia. The maximum dose per day should not exceed 0.5 mg. Caution should be taken in elderly patients and they should receive lower doses. The most common side effects were drowsiness, headache, dizziness/lightheadedness, difficulty with coordination and nausea/vomiting.
Ramelteon was introduced as Rozerem by Takeda Pharmaceuticals North America. Rozerem is indicated for treatment of the type of insomnia that is interferes with sleep onset. Ramelteon is rather unique among commonly prescribed sleep aids in that it is unrelated to benzodiazepines in both its chemical structure and its mechanism of action. Rozerem binds with high affinity (strongly) to two of the three main melatonin receptors in the brain. Melatonin is a hormone that is present naturally in humans. Melatonin is also available without a prescription as an OTC sleep aid. According to Takeda, Rozerem’s affinity and selectivity for specific melatonin receptors make it a more effective sleep aid and less likely to cause side effects than non-prescription melatonin. Because it does not interact with benzodiazepine receptors, ramelteon is essentially without risk of abuse and is therefore not a controlled substance. Clinical studies have shown that ramelteon does not cause physical dependence or rebound insomnia. Ramelteon is available in 8 mg tablets though it occasionally prescribed as two 8 mg tablets to be taken 30 thirty minutes prior to the desired onset of sleep. The most common side effects are drowsiness and dizziness. More on ramelteon.
Ramelteon is under patent to Takeda until March 6, 2017.
Eszopiclone is marketed as Lunesta by Sepracor Inc. for the treatment of insomnia. Lunesta is under patent until 2012 with exclusivity until December 15, 2009. Eszopiclone is available in 1, 2 and 3 mg film-coated tablets. The precise mechanism of action of eszopiclone as a hypnotic is unknown, but it most likely interacts with benzodiazepine receptors. Because of this interaction, eszopiclone is a controlled substance and there is potential for abuse of the drug. Unlike zaleplon, zolpidem and triazolam which are only prescribed for up to three to four weeks, Lunesta has been approved by the FDA for long term use (greater than six months). Long-term trials showed that Lunesta did not cause tolerance meaning that patients did not need larger doses to obtain the same effect. Lunesta is touted as superior to competing medications since it not only initiates sleep but also prevents nighttime waking.
The most common side effects of Lunesta include an unpleasant taste or dry mouth, dizziness, headache, cold symptoms and drowsiness. Serious side effects of eszopiclone, while rare, include sleep walking/driving, abnormal thoughts, memory loss, anxiety and allergic reactions. These rare and serious side effecttransleter
The Convention on the Rights of the Child was adopted and opened for signature, ratification and accession by General Assembly resolution 44/25 of 20 November 1989. It entered into force 2 September 1990, in accordance with article 49.
Status of ratifications
The States Parties to the present Convention,
Considering that, in accordance with the principles proclaimed in the Charter of the United Nations, recognition of the inherent dignity and of the equal and inalienable rights of all members of the human family is the foundation of freedom, justice and peace in the world,
Bearing in mind that the peoples of the United Nations have, in the Charter, reaffirmed their faith in fundamental human rights and in the dignity and worth of the human person and have determined to promote social progress and better standards of life in larger freedom,
Recognizing that the United Nations has, in the Universal Declaration of Human Rights and in the International Covenants on Human Rights, proclaimed and agreed that everyone is entitled to all the rights and freedoms set forth therein, without distinction of any kind, such as race, colour, sex, language, religion, political or other opinion, national or social origin, property, birth or other status,
Recalling that, in the Universal Declaration of Human Rights, the United Nations has proclaimed that childhood is entitled to special care and assistance,
Convinced that the family, as the fundamental group of society and the natural environment for the growth and well-being of all its members and particularly children, should be afforded the necessary protection and assistance so that it can fully assume its responsibilities within the community,
Recognizing that the child, for the full and harmonious development of his or her personality, should grow up in a family environment, in an atmosphere of happiness, love and understanding,
Considering that the child should be fully prepared to live an individual life in society and brought up in the spirit of the ideals proclaimed in the Charter of the United Nations and in particular in the spirit of peace, dignity, tolerance, freedom, equality and solidarity,
Bearing in mind that the need to extend particular care to the child has been stated in the Geneva Declaration of the Rights of the Child of 1924 and in the Declaration of the Rights of the Child adopted by the General Assembly on 20 November 1959 and recognized in the Universal Declaration of Human Rights, in the International Covenant on Civil and Political Rights (in particular in articles 23 and 24), in the International Covenant on Economic, Social and Cultural Rights (in particular in article 10) and in the statutes and relevant instruments of specialized agencies and international organizations concerned with the welfare of children, '
Bearing in mind that, as indicated in the Declaration of the Rights of the Child, "the child, by reason of his physical and mental immaturity, needs special safeguards and care, including appropriate legal protection, before as well as after birth",
Recalling the provisions of the Declaration on Social and Legal Principles relating to the Protection and Welfare of Children, with Special Reference to Foster Placement and Adoption Nationally and Internationally; the United Nations Standard Minimum Rules for the Administration of Juvenile Justice (The Beijing Rules) ; and the Declaration on the Protection of Women and Children in Emergency and Armed Conflict,
Recognizing that, in all countries in the world, there are children living in exceptionally difficult conditions and that such children need special consideration,
Taking due account of the importance of the traditions and cultural values of each people for the protection and harmonious development of the child,
Recognizing the importance of international co-operation for improving the living conditions of children in every country, in particular in the developing countries,
Have agreed as follows:
For the purposes of the present Convention, a child means every human being below the age of eighteen years unless under the law applicable to the child, majority is attained earlier.
1. States Parties shall respect and ensure the rights set forth in the present Convention to each child within their jurisdiction without discrimination of any kind, irrespective of the child's or his or her parent's or legal guardian's race, colour, sex, language, religion, political or other opinion, national, ethnic or social origin, property, disability, birth or other status.
2. States Parties shall take all appropriate measures to ensure that the child is protected against all forms of discrimination or punishment on the basis of the status, activities, expressed opinions, or beliefs of the child's parents, legal guardians, or family members.
1. In all actions concerning children, whether undertaken by public or private social welfare institutions, courts of law, administrative authorities or legislative bodies, the best interests of the child shall be a primary consideration.
2. States Parties undertake to ensure the child such protection and care as is necessary for his or her well-being, taking into account the rights and duties of his or her parents, legal guardians, or other individuals legally responsible for him or her, and, to this end, shall take all appropriate legislative and administrative measures.
3. States Parties shall ensure that the institutions, services and facilities responsible for the care or protection of children shall conform with the standards established by competent authorities, particularly in the areas of safety, health, in the number and suitability of their staff, as well as competent supervision.
States Parties shall undertake all appropriate legislative, administrative and other measures for the implementation of the rights recognized in the present Convention. With regard to economic, social and cultural rights, States Parties shall undertake such measures to the maximum extent of their available resources and, where needed, within the framework of international co-operation.
States Parties shall respect the responsibilities, rights and duties of parents or, where applicable, the members of the extended family or community as provided for by local custom, legal guardians or other persons legally responsible for the child, to provide, in a manner consistent with the evolving capacities of the child, appropriate direction and guidance in the exercise by the child of the rights recognized in the present Convention.
1. States Parties recognize that every child has the inherent right to life.
2. States Parties shall ensure to the maximum extent possible the survival and development of the child.
1. The child shall be registered immediately after birth and shall have the right from birth to a name, the right to acquire a nationality and. as far as possible, the right to know and be cared for by his or her parents.
2. States Parties shall ensure the implementation of these rights in accordance with their national law and their obligations under the relevant international instruments in this field, in particular where the child would otherwise be stateless.
1. States Parties undertake to respect the right of the child to preserve his or her identity, including nationality, name and family relations as recognized by law without unlawful interference.
2. Where a child is illegally deprived of some or all of the elements of his or her identity, States Parties shall provide appropriate assistance and protection, with a view to re-establishing speedily his or her identity.
1. States Parties shall ensure that a child shall not be separated from his or her parents against their will, except when competent authorities subject to judicial review determine, in accordance with applicable law and procedures, that such separation is necessary for the best interests of the child. Such determination may be necessary in a particular case such as one involving abuse or neglect of the child by the parents, or one where the parents are living separately and a decision must be made as to the child's place of residence.
2. In any proceedings pursuant to paragraph 1 of the present article, all interested parties shall be given an opportunity to participate in the proceedings and make their views known.
3. States Parties shall respect the right of the child who is separated from one or both parents to maintain personal relations and direct contact with both parents on a regular basis, except if it is contrary to the child's best interests. 4. Where such separation results from any action initiated by a State Party, such as the detention, imprisonment, exile, deportation or death (including death arising from any cause while the person is in the custody of the State) of one or both parents or of the child, that State Party shall, upon request, provide the parents, the child or, if appropriate, another member of the family with the essential information concerning the whereabouts of the absent member(s) of the family unless the provision of the information would be detrimental to the well-being of the child. States Parties shall further ensure that the submission of such a request shall of itself entail no adverse consequences for the person(s) concerned.
1. In accordance with the obligation of States Parties under article 9, paragraph 1, applications by a child or his or her parents to enter or leave a State Party for the purpose of family reunification shall be dealt with by States Parties in a positive, humane and expeditious manner. States Parties shall further ensure that the submission of such a request shall entail no adverse consequences for the applicants and for the members of their family.
2. A child whose parents reside in different States shall have the right to maintain on a regular basis, save in exceptional circumstances personal relations and direct contacts with both parents. Towards that end and in accordance with the obligation of States Parties under article 9, paragraph 1, States Parties shall respect the right of the child and his or her parents to leave any country, including their own and to enter their own country. The right to leave any country shall be subject only to such restrictions as are prescribed by law and which are necessary to protect the national security, public order (ordre public), public health or morals or the rights and freedoms of others and are consistent with the other rights recognized in the present Convention.
1. States Parties shall take measures to combat the illicit transfer and non-return of children abroad.
2. To this end, States Parties shall promote the conclusion of bilateral or multilateral agreements or accession to existing agreements.
1. States Parties shall assure to the child who is capable of forming his or her own views the right to express those views freely in all matters affecting the child, the views of the child being given due weight in accordance with the age and maturity of the child.
2. For this purpose, the child shall in particular be provided the opportunity to be heard in any judicial and administrative proceedings affecting the child, either directly, or through a representative or an appropriate body, in a manner consistent with the procedural rules of national law.
1. The child shall have the right to freedom of expression; this right shall include freedom to seek, receive and impart information and ideas of all kinds, regardless of frontiers, either orally, in writing or in print, in the form of art, or through any other media of the child's choice.
2. The exercise of this right may be subject to certain restrictions, but these shall only be such as are provided by law and are necessary:
(a) For respect of the rights or reputations of others; or
(b) For the protection of national security or of public order (ordre public), or of public health or morals.
1. States Parties shall respect the right of the child to freedom of thought, conscience and religion.
2. States Parties shall respect the rights and duties of the parents and, when applicable, legal guardians, to provide direction to the child in the exercise of his or her right in a manner consistent with the evolving capacities of the child.
3. Freedom to manifest one's religion or beliefs may be subject only to such limitations as are prescribed by law and are necessary to protect public safety, order, health or morals, or the fundamental rights and freedoms of others.
1. States Parties recognize the rights of the child to freedom of association and to freedom of peaceful assembly.
2. No restrictions may be placed on the exercise of these rights other than those imposed in conformity with the law and which are necessary in a democratic society in the interests of national security or public safety, public order (ordre public), the protection of public health or morals or the protection of the rights and freedoms of others.
1. No child shall be subjected to arbitrary or unlawful interference with his or her privacy, family, home or correspondence, nor to unlawful attacks on his or her honour and reputation.
2. The child has the right to the protection of the law against such interference or attacks.
States Parties recognize the important function performed by the mass media and shall ensure that the child has access to information and material from a diversity of national and international sources, especially those aimed at the promotion of his or her social, spiritual and moral well-being and physical and mental health. To this end, States Parties shall:
(a) Encourage the mass media to disseminate information and material of social and cultural benefit to the child and in accordance with the spirit of article 29;
(b) Encourage international co-operation in the production, exchange and dissemination of such information and material from a diversity of cultural, national and international sources;
(c) Encourage the production and dissemination of children's books;
(d) Encourage the mass media to have particular regard to the linguistic needs of the child who belongs to a minority group or who is indigenous;
(e) Encourage the development of appropriate guidelines for the protection of the child from information and material injurious to his or her well-being, bearing in mind the provisions of articles 13 and 18.
1. States Parties shall use their best efforts to ensure recognition of the principle that both parents have common responsibilities for the upbringing and development of the child. Parents or, as the case may be, legal guardians, have the primary responsibility for the upbringing and development of the child. The best interests of the child will be their basic concern.
2. For the purpose of guaranteeing and promoting the rights set forth in the present Convention, States Parties shall render appropriate assistance to parents and legal guardians in the performance of their child-rearing responsibilities and shall ensure the development of institutions, facilities and services for the care of children.
3. States Parties shall take all appropriate measures to ensure that children of working parents have the right to benefit from child-care services and facilities for which they are eligible.
1. States Parties shall take all appropriate legislative, administrative, social and educational measures to protect the child from all forms of physical or mental violence, injury or abuse, neglect or negligent treatment, maltreatment or exploitation, including sexual abuse, while in the care of parent(s), legal guardian(s) or any other person who has the care of the child.
2. Such protective measures should, as appropriate, include effective procedures for the establishment of social programmes to provide necessary support for the child and for those who have the care of the child, as well as for other forms of prevention and for identification, reporting, referral, investigation, treatment and follow-up of instances of child maltreatment described heretofore, and, as appropriate, for judicial involvement.
1. A child temporarily or permanently deprived of his or her family environment, or in whose own best interests cannot be allowed to remain in that environment, shall be entitled to special protection and assistance provided by the State.
2. States Parties shall in accordance with their national laws ensure alternative care for such a child.
3. Such care could include, inter alia, foster placement, kafalah of Islamic law, adoption or if necessary placement in suitable institutions for the care of children. When considering solutions, due regard shall be paid to the desirability of continuity in a child's upbringing and to the child's ethnic, religious, cultural and linguistic background.
States Parties that recognize and/or permit the system of adoption shall ensure that the best interests of the child shall be the paramount consideration and they shall:
(a) Ensure that the adoption of a child is authorized only by competent authorities who determine, in accordance with applicable law and procedures and on the basis of all pertinent and reliable information, that the adoption is permissible in view of the child's status concerning parents, relatives and legal guardians and that, if required, the persons concerned have given their informed consent to the adoption on the basis of such counselling as may be necessary;
(b) Recognize that inter-country adoption may be considered as an alternative means of child's care, if the child cannot be placed in a foster or an adoptive family or cannot in any suitable manner be cared for in the child's country of origin; (c) Ensure that the child concerned by inter-country adoption enjoys safeguards and standards equivalent to those existing in the case of national adoption;
(d) Take all appropriate measures to ensure that, in inter-country adoption, the placement does not result in improper financial gain for those involved in it;
(e) Promote, where appropriate, the objectives of the present article by concluding bilateral or multilateral arrangements or agreements and endeavour, within this framework, to ensure that the placement of the child in another country is carried out by competent authorities or organs.
1. States Parties shall take appropriate measures to ensure that a child who is seeking refugee status or who is considered a refugee in accordance with applicable international or domestic law and procedures shall, whether unaccompanied or accompanied by his or her parents or by any other person, receive appropriate protection and humanitarian assistance in the enjoyment of applicable rights set forth in the present Convention and in other international human rights or humanitarian instruments to which the said States are Parties.
2. For this purpose, States Parties shall provide, as they consider appropriate, co-operation in any efforts by the United Nations and other competent intergovernmental organizations or non-governmental organizations co-operating with the United Nations to protect and assist such a child and to trace the parents or other members of the family of any refugee child in order to obtain information necessary for reunification with his or her family. In cases where no parents or other members of the family can be found, the child shall be accorded the same protection as any other child permanently or temporarily deprived of his or her family environment for any reason, as set forth in the present Convention.
1. States Parties recognize that a mentally or physically disabled child shoul
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International Labour Day (May
Day) 2014 - May 1 (Thursday)
Post your comments
Happy Labour Day. But I am working
today under the pressure of employer.
This is infringement of your personal
rights, liberty and emotions.I am in DPS
by Nitesh on May 1, 2013 8:21 PM IST Report Abuse
LABOUR DAY IT ONLY FOR PAPER DAY
NOT PUBLIC HOLIDAY
by JEET on May 1, 2013 12:36 PM IST Report Abuse
happy labour day but so sad today i am in
by Mohit Saxena on May 1, 2013 11:48 AM
IST Report Abuse
How ever so many agitations took place to
aware the people about their rights but it
will take along time for man to
understand the feelings of others. All the
private schools pay less and try to take
more work. they even want the teachers
to sit till late nights and even on Sundays
and prepare lessons because they say that
they do not afford the relevant number of
teachers. Being unemployed the teachers
(the most learned laborers of India) have
to work according to the wish of their
employers. Can we say that India is going
to touch the heights of the developments.
by Sherbaj Singh Dhillon on Apr 30, 2013
8:56 PM IST Report Abuse
useful as a
by muskan malik on Apr 29, 2013 6:06 PM
IST Report Abuse
Lots of employees have to work from
morning 6.30 to evening 8.00 on this
labour day due to prssure from high
authorities of HDFC bank. Please take
care of emplyees
by Raaj on May 1, 2012 3:29 PM IST Report Abuse
Today is not holiday in my office :( Comment #2
by Mak on May 1, 2012 10:16 AM IST Report Abuse
i am nileshvora i working in textil vimal
reliance industries limited
ahmedabad.menegment and workar not
sayting in pay to salery 1st may 2012.
by nileshvora on Apr 30, 2012 11:07 PM
IST Report Abuse
May Day, the first day of the month of
May is celebrated all over the world with
utmost importance. The day is also known
as the International Worker’s Day which
has a historic significance. The first day of
the month of May is also a day of political
protests. May Day is otherwise observed
as a saint's feast day or a day for
organized labor. In many countries, it is a
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