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intrinsic clearance is, therefore, reduced coupled with a higher unbound fraction of pioglitazone (see section 4.2).
di conseguenza la clearance intrinseca è ridotta, associata ad una più elevata frazione di pioglitazone non legato (vedere paragrafo 4.2).
the mean intrinsic clearance was 0.016 l/h/m2 (range 0.008-0.027 l/h/m2), the mean central volume of distribution was 1.46 l/m2 (range 1.10-1.64 l/m2).
la clearance intrinseca media era di 0,016 l/h/m2 (intervallo di 0,008–0,027 l/h/m2), il volume di distribuzione medio era 1,46 l/m2 (intervallo 1,10 – 1,64 l/m2).