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fluoxetine is primarily metabolised by the liver to the active metabolite norfluoxetine (desmethylfluoxetine), by desmethylation.
a fluoxetina é metabolizada principalmente pelo fígado no seu metabolito activo norfluoxetina (dimetilfluoxetina), por desmetilação.
Last Update: 2012-04-12
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in vitro studies using human liver microsomes indicate that cyp1a1 is the major enzyme responsible for the 7-hydroxylation of granisetron, whereas cyp3a4 contributes to 9’desmethylation.
estudos in vitro, utilizando microssomas hepáticos humanos, indicam que a cyp1a1 é a principal enzima responsável pela 7-hidroxilação do granissetrom, enquanto que a cyp3a4 contribui para a 9’desmetilação.
Last Update: 2017-04-26
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