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herg gene mutation
mutação no gene herg
Last Update: 2014-12-08
Usage Frequency: 4
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herg gene status assay
ensaio de estado do gene herg
Last Update: 2014-12-08
Usage Frequency: 4
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the gene for lqt2 received the name of herg and is also connected to the potassium canals.
o gene para lqt2 recebeu o nome de herg, e também está ligado aos canais de potássio.
Last Update: 2018-02-13
Usage Frequency: 1
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in the herg test, the ic50 was 0.15 µmol for piperaquine and 7.7 µmol forartenimol.
no ensaio do gene herg a ci50 foi de 0,15 µmol para a piperaquina e de 7,7 µmol para o artenimol.
Last Update: 2017-04-26
Usage Frequency: 1
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pitolisant blocked herg channel with an ic50 exceeding therapeutic concentrations and induced a slight qtc prolongation in dogs.
o pitolisant bloqueou o canal herg com ic50 a exceder as concentrações terapêuticas, e induziu um prolongamento ligeiro do intervalo qt em cães.
Last Update: 2017-04-26
Usage Frequency: 1
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in vitro data show that the ic50 for the inhibitory effect of ceritinib on the herg potassium channel was 0.4 micromolar.
os dados in vitro revelam que a ci50 para o efeito inibitório de ceritinib no canal de potássio herg foi de 0,4 micromolar.
Last Update: 2017-04-26
Usage Frequency: 1
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telithromycin, but not its major human metabolites, had inhibitory activity on herg and kv1.5 channels.
a hipocalemia e a quinidina têm efeitos aditivos / sobreaditivos in vitro, enquanto que a potenciação foi evidente com o sotalol. a telitromicina, mas não os seus metabolitos humanos, tem actividade inibitória no herg e canais kv1. 5.
Last Update: 2011-10-23
Usage Frequency: 1
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non clinical in vitro and in vivo studies have evidenced the potential of toremifene and its metabolite to prolong cardiac repolarisation and this can be attributed to the blockade of herg channels.
estudos não clínicos in vitro e in vivo revelaram o potencial do toremifeno e do seu metabolito para prolongar a repolarização cardíaca, podendo este facto ser atribuído ao bloqueio dos canais herg.
Last Update: 2017-04-26
Usage Frequency: 3
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lower concentrations of lopinavir/ritonavir did not produce significant potassium (herg) current blockade.
concentrações mais baixas de lopinavir/ritonavir não produziram bloqueio significativo no potássio circulante (herg).
Last Update: 2017-04-26
Usage Frequency: 6
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dasatinib activity in vitro in herg and purkinje fiber assays suggested a potential for prolongation of cardiac ventricular repolarization (qt interval).
19 a actividade do dasatinib in vitro em ensaios de fibras de purkinje e herg, sugeriu um potencial para prolongamento da repolarização ventricular cardíaca (intervalo qt).
Last Update: 2012-04-12
Usage Frequency: 4
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during in vitro studies, cloned human cardiac potassium channel (herg) , was inhibited by 15% at a concentration (30 m) of atazanavir corresponding to 30-fold the free drug concentration at cmax in humans.
durante os estudos in vitro, o canal cardíaco de potássio humano clonado (herg) , foi inibido em 15% numa concentração (30 m) de atazanavir correspondente a 30 vezes a concentração de fármaco livre na cmax em humanos.
Last Update: 2008-03-04
Usage Frequency: 5
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