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no dose adjustment is necessary for patients with mild to moderate impaired hepatic function (child pugh class a and b).
prilagoditev odmerka ni potrebna pri bolnikih z blago do zmerno okvaro jeter (razreda a in b po child pugh- u).
hepatic impairment: no dose adjustment is necessary for patients with mild to moderate impaired hepatic function (child pugh class a and b).
okvara jeter: prilagoditev odmerka ni potrebna pri bolnikih z blago do zmerno okvaro jeter (razreda a in b po child pugh-u).
in the single patient studied with severe hepatic impairment (child pugh grade c), half life was doubled indicating a potential for a much greater degree of accumulation.
99 pri edinem bolniku s hudo jetrno okvaro (stopnja c po child pugh- u) je bil razpolovni čas dvakrat daljši, kar kaže na možnost veliko večje akumulacije.