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preaggregated <PROTECTED>142 at 2nm concentration is added to the supersaturated ph 7.4 incubation to seed aggregation of <PROTECTED> 140.
se añade <PROTECTED> 142 a una concentración de 2 nm a la incubación supersaturada a ph 7,4 para promover la agregación de <PROTECTED> 140.
<PROTECTED> 142 is produced less abundantly than the 140 <PROTECTED> peptide (<PROTECTED> et al., 1992; <PROTECTED> et al., 1992), but the preferential deposition of <PROTECTED>142 results from the fact that this coohextended form is more insoluble than 140 <PROTECTED> and is more prone to aggregate and form antiparallel βpleated sheets (<PROTECTED> et al., 1989; <PROTECTED> et al., 1990; <PROTECTED> et al., 1992; <PROTECTED> et al., 1992; <PROTECTED> et al., 1994).
<PROTECTED> 142 se produce en menor abundancia que el péptido <PROTECTED> 140 (<PROTECTED> et al., 1992; <PROTECTED> et al., 1992), pero el depósito preferente de <PROTECTED> 142 es el resultado del hecho de que esta forma extendida en cooh es más insoluble que <PROTECTED> 140 y más propensa a agregarse y a formar hojas plegadas β antiparalelas (<PROTECTED> et al., 1989; <PROTECTED> et al., 1990; <PROTECTED> et al., 1992; <PROTECTED> et al., 1992; <PROTECTED> et al., 1994).
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