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des études in vitro ont démontré que les cyp2c8 et 3a4 sont respectivement impliqués dans la formation du 6 alpha-hydroxypaclitaxel et du 3'-para-dihydroxypaclitaxel.
in vitro studies have shown that cyp2c8 and 3a4 are involved in the formation of 6 alpha-hydroxypaclitaxel and 3'-para-dihydroxypaclitaxel, respectively.
Last Update: 2011-10-23
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6-alpha-hydroxypaclitaxel, 3’ -para-hydroxypaclitaxel et 6 alpha, 3’ -para- dihydroxypaclitaxel.
6 alpha-hydroxypaclitaxel, 3’ -para-hydroxypaclitaxel and 6 alpha, 3’ -para-dihydroxypaclitaxel.
Last Update: 2011-10-23
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selon l'analyse de la littérature, les études menées in vitro sur des microsomes de foie humain et des tranches de tissu indiquent que le paclitaxel est principalement métabolisé en 6-hydroxypaclitaxel et en deux métabolites mineurs, 3'-p-hydroxypaclitaxel et 6-3'-p-dihydroxypaclitaxel.
based on the published literature, in vitro studies with human liver microsomes and tissue slices show that paclitaxel is metabolised primarily to 6-hydroxypaclitaxel; and to two minor metabolites, 3'-p-hydroxypaclitaxel and 6-3'-p-dihydroxypaclitaxel.
Last Update: 2008-03-04
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