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des rats ont été entraínés à discriminer l'effet de stimulus intéroceptif de l'apomorphine (0,2 mg.kg⁻¹ i.p.) de celui du sérum physiologique, selon un principe décrit par colpaert f. dans "drug discrimination application in c.n.s. pharmacology" ed.
table xi______________________________________ % inhibition of hypo- thermia dose mg.kg.sup.-1 i.p.compound 2.5 5 10 20______________________________________example 2 -62.sup.s -27 -32.sup.s -47.sup.sexample 6 -1 +1 -24 -20example 9 -8 +37 +16 +11example 12 -23 -45.sup.s -18example 27 -13 -21example 32 -1 -29.sup.sexample 35 -20 -4example 38 -28 -35 -21example 39 +37 +14 +6 +15example 40 +14 +14example 41 +13 +29.sup.s______________________________________ table xii______________________________________compound ed.sub.50 (mg.kg.sup.-1 i.v.)______________________________________example 2 0.146example 3 0.130example 6 0.498example 9 0.173example 12 > 2.52______________________________________ example 47 drug discrimination in rats the dopamine-stimulating property of the compounds of the invention was demonstrated by drug discrimination experiments in rats. rats were trained to discriminate between the effects of the interoceptive stimulus of apomorphine (0.2 mg.kg.sup.-1 i.p.) and that of physiological saline, according to a principle described by colpaert f. in "drug discrimination application in c.n.s. pharmacology" ed.