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inhibiteurs de l'histone desacetylase pour le traitement de maladies et de troubles oculaires, neovasculaires ou oedemateux
histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases
ainsi, à la dose de 20 mg/kg i.v., les composés des exemples 1 et 2 diminuent significativement le volume de l'infarctus oedemateux cortical de 45 et 27 % respectivement.
thus, at the dose of 20 mg/kg i.v., the compounds of examples 1 and 2 significantly reduce the cortical edematous infarct volume by 45 and 27% respectively.