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a nelarabin a deoxiguanozin-analóg ara-g elővegyülete (pro-drug).
nelarabine is a pro-drug of the deoxyguanosine analogue ara-g.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
a nelarabint az adenozin-deamináz (ada) igen gyorsan ara-g-vé demetilezi, majd a deoxiguanozin-kináz és deoxicitidin-kináz intracellulárisan 5’-monofoszfáttá foszforilálja.
nelarabine is rapidly demethylated by adenosine deaminase (ada) to ara-g and then phosphorylated intracellularly by deoxyguanosine kinase and deoxycytidine kinase to its 5’-monophosphate metabolite.
Last Update: 2017-04-26
Usage Frequency: 5
Quality: