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adakah aku tidak layak dipertahankan?
it's not worth me being ke
Last Update: 2024-03-15
Usage Frequency: 1
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apa ini masih ada
这个还有吗
Last Update: 2022-02-19
Usage Frequency: 1
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selama persediaan masih ada
applies multiply
Last Update: 2019-04-18
Usage Frequency: 1
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masih ada yang ditutupi dari saya
the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors. the most potent suppressors of gastric acid secretion are inhibitors of the gastric h+,k+-atpase (proton pump) (figure 36–2a). in typical doses, these drugs diminish the daily production of acid (basal and stimulated) by 80% to 95%. five proton pump inhibitors are available for clinical use: omeprazole (prilosec, rapinex, zegerid) and its s-isomer, esomeprazole (nexium), lansoprazole (prevacid), rabeprazole (aciphex), and pantoprazole (protonix). these drugs have different substitutions on their pyridine and/or benzimidazole groups but are remarkably similar in their pharmacological properties (see appendix ii). omeprazole is a racemic mixture of r- and s-isomers; the s-isomer, esomeprazole (s-omeprazole), is eliminated less rapidly than r-omeprazole, which theoretically provides a therapeutic advantage because of the increased half-life. despite claims to the contrary, all proton pump inhibitors have equivalent efficacy at comparable doses. proton pump inhibitors are prodrugs that require activation in an acid environment. after absorption into the systemic circulation, the prodrug diffuses into the parietal cells of the stomach and accumulates in the acidic secretory canaliculi. here, it is activated by proton-catalyzed formation of a tetracyclic sulfenamide (figure 36–2), trapping the drug so that it cannot diffuse back across the canalicular membrane. the activated form then binds covalently with sulfhydryl groups of cysteines in the h+,k+-atpase, irreversibly inactivating the pump molecule. acid secretion resumes only after new pump molecules are synthesized and inserted into the luminal membrane, providing a prolonged (up to 24- to 48-hour) suppression of acid secretion, despite the much shorter plasma half-lives (0.5 to 2 hours) of the parent compounds. because they block the final step in acid production, the proton pump inhibitors are effective in acid suppression regardless of other stimulating factors.
Last Update: 2014-04-24
Usage Frequency: 1
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berlaku selama persediaan masih ada
while supplies last
Last Update: 2019-04-12
Usage Frequency: 1
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masih ada syarat yang harus dilengkapi
there are still obstacles
Last Update: 2012-04-22
Usage Frequency: 1
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dia menjawab: "masih ada tambahan?"
it will say, "are there any more (to come)?"
Last Update: 2014-07-03
Usage Frequency: 2
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biarlah kita merendahkan diri dan menyerah, karena mungkin harapan masih ada
he putteth his mouth in the dust; if so be there may be hope.
Last Update: 2012-05-06
Usage Frequency: 1
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wabah virus covid 19 masih ada saat ini, covid 19 awalnya berasal dari china
the covid 19 virus outbreak still exists today, covid 19 originally came from china
Last Update: 2022-03-23
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sudah tamat kuliah kenapa masih ada bimbingan sama dosen lagi agar bisa diperbolehkan jilid skripsi ??
already graduated from college why there is still the same guidance teacher again?
Last Update: 2010-10-28
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jangan bersedih,ada aku disini yang selalu mencintaimu
don't be sad, there is me here
Last Update: 2024-04-15
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daerah crystal creek, sis barat black range semakin parah - mengungsi sekarang, selama masih ada kesempatan
strictly, a writer and web publisher living in brisbane, provided a lot of information.
Last Update: 2016-02-24
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