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tādēļ uzskata, ka ustekinumabs nespēj veicināt komplementa vai antivielu pastarpināto receptorus saturošās šūnas citotoksiskumu.
thus, ustekinumab is not likely to contribute to complement- or antibody-mediated cytotoxicity of the receptor-bearing cell.
Last Update: 2012-04-10
Usage Frequency: 2
Quality:
taču metotreksāta poliglutamāts inhibē timidilāta sintāzi un dihidrofolāta reduktāzi, potenciāli palielinot 5- fu citotoksiskumu.
however, polyglutamated methotrexate inhibits thymidylate synthase and dihydrofolate reductase, potentially increasing cytotoxicity of 5-fu.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
to var pierādīt, demonstrējot modeļa noturību pret citotoksiskumu pēc tam, kad pielietotas vielas, kas zināmas kā citotoksiskas, bet kuras parasti netiek cauri raga slānim.
this can be shown by demonstrating the model's resistance to cytotoxicity following the application of substances which are known to be cytotoxic to cells, but which do not normally pass through the stratum corneum.
Last Update: 2014-11-21
Usage Frequency: 2
Quality:
taču folināta/folīnskābes metabolīti veido trīskāršo struktūru ar timidilāta sintāzi un fluordeoksiuridīna monofosfātu (fdump), kas potenciāli palielina 5-fu citotoksiskumu.
however, metabolites of folinate/folinic acid will form a ternary structure with thymidylate synthase and fluorodeoxyuridine monophosphate (fdump), potentially increasing the cytotoxicity of 5-fu.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
uzskata, ka mtik citotoksiskums galvenokārt saistīts ar guanīna o6 pozīcijas alkilēšanu, kā arī papildus ar n7 pozīcijas alkilēšanu.
the cytotoxicity of mtic is thought to be due primarily to alkylation at the o6 position of guanine with additional alkylation also occurring at the n7 position.
Last Update: 2017-04-26
Usage Frequency: 3
Quality: