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lamotrigīns nedaudz inhibē dihidrofolātreduktāzi, tādēļ ilgstošas terapijas gadījumā ir iespējami folātu metabolisma traucējumi (skatīt apakšpunktu 4. 6).
lamotrigine has a slight inhibitory effect on dihydrofolic acid reductase, hence there is a possibility of interference with folate metabolism during long-term therapy (see section 4.6).
Last Update: 2012-04-10
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lai gan vienlaicīga dihidrofolātreduktāzes inhibitoru (piemēram, metotreksāta, trimetoprīma) lietošana nav pētīta, šādas zāles var kavēt bh4 metabolismu.
although concomitant administration of inhibitors of dihydrofolate reductase (e.g. methotrexate, trimethoprim) has not been studied, such medicinal products may interfere with bh4 metabolism.
Last Update: 2017-04-26
Usage Frequency: 3
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