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neskatoties uz palielinātu risku, kas novērots paildzinātos klīniskos pētījumos, kas seko oriģinālo preparātu tirdzniecībai, ir bijuši ziņojumi par retiem kuņģa un duodena čūlu gadījumiem, no kuriem daži bijuši smagi un ar komplikācijām.
despite no increased risk having been observed in extensive clinical trials, following marketing of the original preparation there have been reports of rare cases of gastric and duodenal ulcers, some of them severe and with complications.
Last Update: 2012-04-10
Usage Frequency: 2
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in vitro pētījumos ar žurkām atazanavīrs neierosināja mikrokodolus kaulu smadzenēs, dns bojājumus duodenum („komētas” tests) vai neparedzētas dns izlabošanu aknās un plazmā audu koncentrācijā, kas pārsniedz klastogēnisku koncentrāciju in vitro.
in in vivo studies in rats, atazanavir did not induce micronuclei in bone marrow, dna damage in duodenum (comet assay), or unscheduled dna repair in liver at plasma and tissue concentrations exceeding those that were clastogenic in vitro.
Last Update: 2017-04-26
Usage Frequency: 3
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