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historicamente, seu emprego, no tratamento da asma, nasceu de uma sugestão de william withering que, em 1786, recomendou café forte como um remédio para os sintomas asmáticos.
in 1786, william withering suggested theophylline use in asthma therapy, recommending strong coffee as a remedy for asthma symptoms.
william withering (17 de março de 1741 — 6 de outubro de 1799) foi um médico e botânico britânico, célebre pela descoberta da digitalina.
william withering frs (17 march 1741 – 6 october 1799) was an english botanist, geologist, chemist, physician and the discoverer of digitalis.
em 1785, withering publicou um trabalho "the foxglove and some of its medical uses", que contem informações sobre provas clínicas e notas sobre a toxicidade da digitalis.
in 1785, withering published "an account of the foxglove and some of its medical uses", which contained reports on clinical trials and notes on digitalis's effects and toxicity.
(contribuição de takis fotopoulos: "the crisis of the growth economy, the withering away of the nation-state and the community-based society").
(takis fotopoulos contribution: "the crisis of the growth economy, the withering away of the nation-state and the community-based society").