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astfel este inhibată calea de transducţie calciu - dependentă a semnalului limfocitelor t, prevenind transcripţia unor gene care codifică limfokinele.
the fkbp12-tacrolimus complex specifically and competitively binds to and inhibits calcineurin, leading to a calcium-dependent inhibition of t-cell signal transduction pathways, thereby preventing transcription of a discrete set of lymphokine genes.
Last Update: 2011-10-23
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principalul mod de acţiune al fluorochinolonelor implică interacţiunea cu enzime esenţiale pentru funcţiile majore ale adn-ului cum ar fi replicarea, transcripţia şi recombinarea.
the primary mode of action of the fluoroquinolones involves interaction with enzymes essential for major dna functions such as replication, transcription and recombination.
Last Update: 2017-04-26
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acidul colic reglează descendent biosinteza acizilor biliari prin activarea receptorului x farnesoid, care reprimă transcripţia genei cyp7a1 ce codează colesterol 7α- hidroxilaza, enzima de limitare a vitezei de sinteză a acizilor biliari.
cholic acid down-regulates bile acid biosynthesis via activation of farnesoid x receptor, which represses transcription of the cyp7a1 gene encoding cholesterol 7α-hydroxylase, the rate-limiting enzyme of bile acid synthesis.
Last Update: 2017-04-26
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acest efect clinic a fost asociat cu o reducere mai mare a transcripţiilor bcr-abl la pacienţii trataţi cu imatinib comparativ cu braţul cu chimioterapie după 2 săptămâni de tratament (p=0,02).
this clinical effect was associated with a higher reduction in bcr- abl transcripts in the imatinib-treated patients than in the chemotherapy arm after 2 weeks of therapy (p=0.02).
Last Update: 2017-04-26
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