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entekavir trifosfat s kompeticijo z naravnim substratom deoksigvanozin trifosfatom funkcionalno zavira 3 aktivnosti virusne polimeraze:
by competing with the natural substrate deoxyguanosine tp, entecavir-tp functionally inhibits the 3 activities of the viral polymerase:
Last Update: 2012-04-11
Usage Frequency: 2
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trifosfat gcv kompetitivno zavira vgrajevanje deoksigvanozin-trifosfata (dgtp) v podaljšujočo dna, s čimer ubija množeče se celice.
triphosphate gcv competitively, inhibits incorporation of deoxyguanosine triphosphate (dgtp) into elongating dna, thus killing the proliferating cells.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
nelarabin se z adenozin-deaminazo (ada) hitro demetilira v ara-g, v celici pa se nato z deoksigvanozin-kinazo in deoksicitidin-kinazo fosforilira v 5’-monofosfatni presnovek.
nelarabine is rapidly demethylated by adenosine deaminase (ada) to ara-g and then phosphorylated intracellularly by deoxyguanosine kinase and deoxycytidine kinase to its 5’-monophosphate metabolite.
Last Update: 2017-04-26
Usage Frequency: 3
Quality: