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poleg tega aripiprazol in dehidroaripiprazol in vitro nista pokazala potenciala za spreminjanje presnove s cyp1a2.
adicionalmente, o aripiprazol e o dehidro- aripiprazol não mostraram potencial para alterar in vitro o metabolismo mediado pela cyp1a2.
Last Update: 2012-04-11
Usage Frequency: 2
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v stanju dinamičnega ravnovesja predstavlja aktivni presnovek dehidroaripiprazol okrog 40% auc aripiprazola v plazmi.
no estado de equilíbrio, o dehidro- aripiprazol, o metabolito activo, representa cerca de 40% da auc do aripiprazol no plasma.
Last Update: 2012-04-11
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v terapevtskih koncentracijah sta aripiprazol in dehidroaripiprazol več kot 99% vezana na beljakovine v serumu, predvsem na albumin.
em concentrações terapêuticas, a ligação do aripiprazol e do dehidro- aripiprazol às proteínas séricas é superior a 99%, ligando- se principalmente à albumina.
Last Update: 2012-04-11
Usage Frequency: 2
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