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detta indikerar omfattande icke- renal clearance.
in patients with metastatic breast cancer, after a 30 minute infusion of abraxane at 260 mg/ m2, the mean value for cumulative urinary excretion of unchanged active substance accounted for 4% of the total administered dose with less than 1% as the metabolites 6α -hydroxypaclitaxel and 3’ -p-hydroxypaclitaxel, indicating extensive non-renal clearance.