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att fortsätta undersöka värdet av andra biomarkörer än pd-l1-uttryck på tumörcellmembrannivå genom ihc (t.ex. andra genombaserade metoder/tester och associerade cut-off-nivåer som kan visa sig känsligare och mer specifika i att förutsäga hur man svarar på behandlingen baserat på pd-l1, pd-l2, tumörinfiltrerande lymfocyter mätt med cd8+t densitet, rna signatur, uttryck av komponenter av antigenpresenterande komplex och/eller andra checkpointhämmarreceptorer/ligander inom tumören etc.) som prediktorer för effekt av nivolumab och/eller nivolumab + ipilimumab kombinationsbehandling.
to further investigate the value of biomarkers other than pd-l1 expression status at tumour cell membrane level by ihc (e.g., other genomic-based methods / assays, and associated cut-offs, that might prove more sensitive and specific in predicting response to treatment based on pd-l1, pd-l2, tumour infiltrating lymphocytes with measurement of cd8+t density, rna signature, expression of components of antigen-presentation complexes and/or other inhibitory checkpoint receptors/ligands within tumour, etc.) as predictive of nivolumab and/or nivolumab + ipilimumab combination therapy efficacy.