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komorbiditet i tillæg til den underliggende malignitet samt andre lægemidler forekom også hyppigt.
co-morbidities in addition to the underlying malignancy were also frequently present as were concomitant medicinal products.
88 % af forsøgspersonerne havde signifikant komorbiditet (fx infektion, nedsat hjertefunktion, nedsat lungefunktion).
eighty-one percent of subjects had significant comorbidities (e.g., infection, cardiac impairment, pulmonary impairment).
forekomsten af pneumokoksygdom hos børn og teenagere i alderen 5-17 år er lav, men der er en øget risiko for morbiditet og mortalitet ved underliggende komorbiditet.
in children and adolescents aged 6 to 17 years, the incidence of pneumococcal disease is low, however, there is an increased risk of morbidity and mortality in those with underlying comorbidities.
de berørte patienter har ofte komorbiditet af væsentligt omfang, herunder nedsat cns-funktion, som ikke behandles ved korrektion af virkningerne af galdesyredefekten.
affected patients often present with significant comorbidities, including cns impairment, which would not be treated by addressing the bile defect effects.
patienter med ecog-performancestatus ≥2 eller med signifikant komorbiditet kan have større risiko for et dårligt klinisk resultat og bør overvåges nøje for tidlig klinisk forværring.
patients with ecog performance status ≥2 or having significant co-morbidities may be at greater risk for a poor clinical outcome and should be carefully monitored for early clinical deterioration.
anvendelsen af prevenar 13 bør baseres på officielle anbefalinger under hensyntagen til risikoen for invasiv sygdom og pneumoni hos forskellige aldersgrupper, underliggende komorbiditet samt variabiliteten af serotype-epidemiologi i forskellige geografiske områder.
the use of prevenar 13 should be determined on the basis of official recommendations taking into consideration the risk of invasive disease and pneumonia in different age groups, underlying comorbidities as well as the variability of serotype epidemiology in different geographical areas.
der foreligger ingen data om dosis og tidsinterval for celvapan- vaccinering for personer under 18 år og for personer med komorbiditet (f. eks. personer med immunosuppression).
there is no data on celvapan vaccination dose and schedule for subjects under 18 years old and for subjects with co-morbidities (e. g. immunosuppressed subjects).
den forebyggende behandling af peptisk ulceration hos patienter, der kræver fortsat nsaid - behandling, skal begrænses til højrisikopatienter (f. eks. tidligere gastrointestinal blødning, perforation eller ulcus, fremskreden alder, samtidig brug af medicin, der er kendt for at øge sandsynligheden for bivirkninger i den øvre gastrointestinalkanal [f. eks. kortikosteroider eller antikoagulantia], tilstedeværelse af en alvorlig faktor for komorbiditet eller forlænget brug af de maksimalt anbefalede doser af nsaid).
the treatment for the prevention of peptic ulceration of patients in need of continuous nsaid treatment should be restricted to high risk patients (e.g. previous gastrointestinal bleeding, perforation or ulcer, advanced age, concomitant use of medication known to increase the likelihood of upper gi adverse events [e.g. corticosteroids or anticoagulants], the presence of a serious co-morbidity factor or the prolonged use of nsaid maximum recommended doses).