Spironolakton

Spironolactone

PRILACTONE 10 mg tabletter Spironolakton
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PRILACTONE 10 mg tablets Spironolactone
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En tablett innehåller 10 mg spironolakton
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Each tablet contains 10 mg spironolactone
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PRILACTONE 80 mg tabletter till hund Spironolakton

PRILACTONE 80 mg tablets for dogs Spironolactone.

Eliminering Spironolakton elimineras huvudsakligen via sina metaboliter.
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Elimination Spironolactone is mainly excreted via its metabolites.
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Spironolakton förhindrar aldosteronets skadliga effekter på det kardiovaskulära systemet.

In the cardiovascular system, spironolactone prevents the detrimental effects of aldosterone.

3 Samtidig användning av spironolakton (se avsnitt 4. 5).
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Concomitant use with spironolactone (see section 4.5)
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I kombinationsbehandling med ACE- hämmare kan spironolakton motverka effekterna av "aldosteronläckage ”.
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When used in combination with ACE-inhibitors, spironolactone may counteract the effects of “ aldosterone escape”.
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Spironolakton minskar elimineringen av digoxin vilket ökar serumplasmanivån av digoxin.

Spironolactone decreases digoxin elimination and hence raises digoxin plasma concentration.

Kall ej ges till växande hundar då spironolakton utövar en antiandrogen effekt.
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As spironolactone has an antiandrogenic effect, it is not recommended to administer the product to growing dogs.
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Hundar på samtidig behandling med spironolakton och NSAID skall hydreras korrekt.

Dogs treated concomitantly with spironolactone and NSAIDs should be correctly hydrated.

- om du behandlas med läkemedel som innehåller spironolakton (se ” Användning av andra
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- if you are being treated with medicines containing spironolactone (see "Using other
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Spironolakton är ett natriuretiskt läkemedel (historiskt beskriven som ett svagt diuretikum).
http://www.emea.europa.eu/

Spironolactone is a natriuretic drug (historically described as a soft diuretic).
http://www.emea.europa.eu/

Farmakokinetiken för spironolakton baseras på dess metaboliter, då spironolakton är instabilt i testmodeller.

The pharmacokinetics of spironolactone are based on its metabolites, as the parent compound is unstable at assay.

Prilactone 10 mg Prilactone 40 mg Prilactone 80 mgspironolakton 10 mg spironolakton 40 mg spironolakton 80 mg

PRILACTONE 10 mg PRILACTONE 40 mg PRILACTONE 80 mg For a full list of excipients, see

Eftersom spironolakton bryts ned i levern ska tabletterna ges med försiktighet till hundar med leversjukdom.

As spironolactone is broken down in the liver, the tablets should be used with caution in dogs with liver disease.

PRILACTONE tabletter innehåller det aktiva ämnet spironolakton (10 mg, 40 mg eller 80 mg) .

PRILACTONE tablets contain the active substance spironolactone (10 mg, 40 mg or 80 mg) .

Prilactone 10 mg spironolakton 10 mg Prilactone 40 mg spironolakton 40 mg Prilactone 80 mg spironolakton 80 mg Hjälpämnen innefattar även biffarom.

Each tablet contains:PRILACTONE 10 mg PRILACTONE 40 mg PRILACTONE 80 mg

Spironolakton inklusive metaboliter (inbegripet 7α- tiometyl- spironolakton och kanrenon) verkar som specifika aldosteronantagonister och utövar effekt genom kompetetiv bindning mineralkortikoidreceptorer i njurar, hjärta och blodkärl.
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Spironolactone and its active metabolites (including 7α -thiomethyl-spironolactone and canrenone) act as specific antagonists of aldosterone, and exert their effects by binding competitively to the mineralocorticoid receptor located in the kidneys, heart and blood vessels.
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2 mg spironolakton/kg kroppsvikt en gång dagligen.

2 mg of spironolactone per kg of body weight once daily.