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the foetal malformations associated with exposure to isotretinoin include central nervous system abnormalities (hydrocephalus, cerebellar malformation/ abnormalities, microcephaly), facial dysmorphia, cleft palate, external ear abnormalities (absence of external ear, small or absent external auditory canals), eye abnormalities (microphthalmia), cardiovascular abnormalities (conotruncal malformations such as tetralogy of fallot, transposition of great vessels, septal defects), thymus gland abnormality and parathyroid gland abnormalities.
Ασθενείς Υψηλού Κινδύνου Σε ασθενείς µε διαβήτη, παχυσαρκία, αλκοολισµό ή κάποια διαταραχή του µεταβολισµού των λιπιδίων που υποβάλλονται σε θεραπεία µε ισοτρετινοΐνη, µπορεί να απαιτούνται συχνότεροι έλεγχοι των τιµών λιπιδίων ορού και/ ή γλυκόζης αίµατος.
Última atualização: 2011-10-23
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