En hydroxymetabolit er blevet fundet i plasma ved lave koncentrationer (mindre end 10% af valsartans AUC) .

A hydroxy metabolite has been identified in plasma at low concentrations (less than 10% of the valsartan AUC) .

En hydroxymetabolit er blevet identificeret i plasma i lave koncentrationer (mindre end 10% af valsartans AUC).
http://www.emea.europa.eu/

A hydroxy metabolite has been identified in plasma at low concentrations (less than 10% of the valsartan AUC).
http://www.emea.europa.eu/

Selv om glimepirids hydroxymetabolit gav et lille men signifikant fald i serumglukose, er denne metabolit kun ansvarlig for en mindre del af den totale virkning.

Although the hydroxy metabolite of glimepiride caused a small but significant reduction in serum glucose, it accounts for only a minor part of the total drug effect.

4 - oxo - og 4- hydroxymetabolit epimere par er de primære metabolitter med antiviral effekt, men de udgør kun en lille del af den samlede plasmaradioaktivitet.
http://www.emea.europa.eu/

The 4-oxo and 4-hydroxymetabolite epimeric pair are the major metabolites with antiviral activity, but comprise only minute amounts of total plasma radioactivity.
http://www.emea.europa.eu/

Selvom glimepirids hydroxymetabolit gav et lille, men signifikant fald i serumglukose hos raske personer, står denne metabolit kun bag en mindre del af den totale virkning.

Although the hydroxy metabolite of glimepiride caused a small but significant decrease in serum glucose in healthy persons, it accounts for only a minor part of the total effect.

AUC og Cmax for clarithromycin blev reduceret med henholdsvis 39% og 26%, hvorimod AUC og Cmax for clarithromycins aktive hydroxymetabolit blev forøget med henholdsvis 34% og 49%, når det blev anvendt i kombination med efavirenz.

The AUC and Cmax of clarithromycin decreased 39% and 26%, respectively, while the AUC and Cmax of the active clarithromycin hydroxymetabolite were increased 34% and 49%, respectively, when used in combination with efavirenz.

Derudover sås cholelithiasis som følge af udfældning af sulfatkonjugater af hydroxymetabolitter af aripiprazol i galden hos aber efter gentagne orale doser på 25-125 mg/kg/dag (1-3 gange middel -steady-state AUC ved den maksimale, anbefalede kliniske dosis eller 16-81 gange den anbefalede, humane dosis baseret på mg/m2) .

An additional finding was cholelithiasis as a consequence of precipitation of sulphate conjugates of hydroxy metabolites of aripiprazole in the bile of monkeys after repeated oral dosing at 25 to 125 mg/kg/day (1 to 3 times the mean steady-state AUC at the maximum recommended clinical dose or 16 to 81 times the maximum recommended human dose based on mg/m2) .

Koncentrationen af 4'-hydroxymetabolitten i plasma og synovialvæsken er lav, og bidrager dermed med al sandsynlighed ikke til effekten.

The concentration of 4'-hydroxy metabolite in plasma and synovial fluid is low, thus it is unlikely to contribute to efficacy.

Koncentrationen af 4 ’ - hydroxymetabolitten i plasma og synovialvæsken er lav, og bidrager dermed med al sandsynlighed ikke til effekten.
http://www.emea.europa.eu/

The concentration of 4’ -hydroxy metabolite in plasma and synovial fluid is low, thus it is unlikely to contribute to efficacy.
http://www.emea.europa.eu/

4 ’ - hydroxymetabolitten har samme potens og COX- 2 selektivitet som lumiracoxib.
http://www.emea.europa.eu/

The 4’ -hydroxy metabolite has similar potency and COX-2 selectivity to lumiracoxib.
http://www.emea.europa.eu/

26% (15 til 35) Clarithromycin 14-hydroxymetabolit:

26% (15 to 35) Clarithromycin 14-hydroxymetabolite:

4-oxo -og 4 -hydroxymetabolit epimere par er de primære metabolitter med antiviral effekt, men de udgør kun en lille del af den samlede plasmaradioaktivitet.

17 in man.The 4-oxo and 4-hydroxymetabolite epimeric pair are the major metabolites with antiviral activity, but comprise only minute amounts of total plasma radioactivity.

4-oxo -og 4 -hydroxymetabolit epimere par er de primære metabolitter med antiviral effekt, men de udgør kun en lille del af den samlede plasmaradioaktivitet.

The 4-oxo and 4-hydroxymetabolite epimeric pair are the major metabolites with antiviral activity, but comprise only minute amounts of total plasma radioactivity.

4'-hydroxymetabolitten har samme potens og COX-2 selektivitet som lumiracoxib.

The 4'-hydroxy metabolite has similar potency and COX-2 selectivity to lumiracoxib.