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rezistentiskumas:
resistance:
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· insulino rezistentiskumas.
· insulin resistance.
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kryzminis rezistentiskumas tarp tetraciklin yra daznas.
cross-resistance is frequent between tetracyclines.
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insulino rezistentiskumas reiskia, kad normalus insulino poveikis
insulin resistance means that the normal effect of insulin on muscle, fat, and
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in vivo rezistentiskumas (antiretrovirusiniais vaistais dar negydytiems pacientams):
in vivo resistance (antiretroviral-naïve patients):
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· genotipinis viruso rezistentiskumas efavirenzui, daugiausia k103n mutacija, issivyst
· genotypic resistance to efavirenz, predominantly the k103n mutation, developed in virus from
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tai gali reiksti, kad issivyst ziv viruso rezistentiskumas isentress ir j tapo sunkiau gydyti.
this may mean that the hiv virus will develop resistance to isentress and become harder to treat.
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dl aiskaus veikimo mechanizmo retapamulinui nra bdingas taikiniui specifinis kryzminis rezistentiskumas su kitomis antibakterini preparat klasmis.
due to its distinct mechanism of action, retapamulin does not demonstrate target specific cross-resistance with other classes of antibacterial agents.
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30 si pacient is 36 (83%) pasireisk rezistentiskumas gydymui (taciau gydym jie toleravo) .
of these patients 30/36 (83%) were treatment resistant not intolerant.
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esant 150l ir 150v substitucijoms, nuo kuri priklauso selektyvus rezistentiskumas atitinkamai atazanavirui ir amprenavirui, kryzminio rezistentiskumo atazanavirui ir amprenavirui nebuvo stebta.
there was no evidence of cross-resistance between atazanavir and amprenavir, with the presence of the i50l and i50v substitutions yielding selective resistance to atazanavir and amprenavir, respectively.
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rezistentiskumas in vivo.antiretrovirusiniais vaistais negydytiems ligoniams 150l substitucija (kartais kartu su a71v pakitimu) yra rezistentiskos atazanavirui mutacijos pozymis.
resistance in vivo: in antiretroviral treatment naive patients, the i50l substitution, sometimes in combination with an a71v change, is the signature resistance mutation for atazanavir.
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10 rezistentiskumas: rezistentiskumas in vitro kai kuriems ziv-1 infekuotiems pacientams emtricitabinui issivysto dl m184v/i mutacijos arba tenofovirui dl k65r mutacijos.
10 resistance:resistance has been seen in vitro and in some hiv-1 infected patients due to the development of the m184v/i mutation with emtricitabine or the k65r mutation with tenofovir.
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insulino dienos poreikis gali bti didesnis, jei yra rezistentiskumas insulinui (pvz., brstant ar nutukus) , ir mazesnis pacientams su sumazjusia endogeninio insulino gamyba.
the daily insulin requirement may be higher in patients with insulin resistance (e. g. during puberty or due to obesity) and lower in patients with residual, endogenous insulin production.
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su sudtiniu antiretrovirusiniu gydymu buvo siejami tokie metabolizmo sutrikimai kaip hipertrigliceridemija, hipercholesterolemija, rezistentiskumas insulinui, hiperglikemija ir hiperlaktatemija (zr.4. 4 skyri) .
combination antiretroviral therapy has been associated with metabolic abnormalities such as hypertriglyceridaemia, hypercholesterolaemia, insulin resistance, hyperglycaemia and hyperlactataemia (see section 4.4) .
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pasirinkti gydymui reyataz reikia tik vertinus individuali virusologini rezistentiskumo tyrim duomenis ir ligoni gydymo anamnez (zr.5. 1 skyri) .
the choice of reyataz should be based on individual viral resistance testing and the patient 's treatment history (see section 5.1) .
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