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in vitro svækker abatacept human t- lymfocytaktivering målt ved nedsat proliferation og cytokinproduktion.
in vitro vermindert abatacept activering van humane t lymfocyten zoals die door verminderde proliferatie en cytokineproductie wordt gemeten.
Last Update: 2012-04-12
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farmakodynamisk effekt med abatacept sås derdosisafhængige fald i serumniveauer af opløselig interleukin- 2- receptor, en markør for t- lymfocytaktivering; serum interleukin- 6 (et produkt af aktiverede synovia- makrofager og fibroblast- lignende synoviocytter i reumatoid artritis); reumatoid faktor (et autoantistof dannet af plasmaceller) samt c- reaktivt protein (en akutfase- reaktant for inflammation).
tevens waren serumspiegels van matrix metalloproteinase-3, dat zorgt voor
Last Update: 2011-10-23
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