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en metaanalyse af patienter med moderat til svær alzheimers sygdom (med en samlet mmse- score < 20) fra de seks fase iii, placebokontrollerede undersøgelser af 6 måneders varighed (inkl. monoterapiundersøgelser og undersøgelser med patienter behandlet med fastdosis acetylkolinesterasehæmmere) viste, at memantin havde en statistisk signifikant effekt på de kognitive, globale og funktionelle domæner.
a meta-analysis of patients with moderate to severe alzheimer’ s disease (mmse total scores < 20) from the six phase iii, placebo-controlled, 6-month studies (including monotherapy studies and studies with patients on a stable dose of acetylcholinesterase inhibitors) showed that there was a statistically significant effect in favour of memantine treatment for the cognitive, global, and functional domains.
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