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i rotter og hunde blev der observeret forhøjet plasmareninaktivitet og hypertrofi/hyperplasi af de juxtaglomerulære nyreceller.
in rats and dogs, increased plasma renin activity and hypertrophy/hyperplasia of the renal juxtaglomerular cells were observed.
hos begge arter blev der observeret forøget plasmareninaktivitet og hypertrofi/hyperplasi af de renale juxtaglomerulære celler.
in both species, increased plasma renin activity and hypertrophy/hyperplasia of the renal juxtaglomerular cells were observed.
hos begge arter sås øget plasma-reninaktivitet og hypertrofi/hyperplasi af de renale juxtaglomerulære celler.
in both species, increased plasma renin activity and hypertrophy/hyperplasia of the renal juxtaglomerular cells were observed.
ved terapeutiske doser af irbesartan hos mennesker synes hyperplasi/ hypertrofi af de renale juxtaglomerulære celler ikke at have nogen relevans.
for therapeutic doses of irbesartan in humans, the hyperplasia/ hypertrophy of the renal juxtaglomerular cells does not appear to have any relevance.
ved terapeutiske doser af irbesartan til mennesker, synes hyperplasi/hypertrofi af de renale juxtaglomerulære celler ikke at have nogen relevans.
for therapeutic doses of irbesartan in humans, the hyperplasia/hypertrophy of the renal juxtaglomerular cells does not appear to have any relevance.
derudover inducerede irbesartan hyperplasi/ hypertrofi af de juxtaglomerulære celler (hos rotter ved ≥ 90 mg/ kg/ dag, hos makakaber ved ≥ 10 mg/ kg/ dag).
furthermore, irbesartan induced hyperplasia/ hypertrophy of the juxtaglomerular cells (in rats at ≥ 90 mg/ kg/ day, in macaques at ≥ 10 mg/ kg/ day).