Valdecoxibs plasmaclearance (CLp) er ca.6 l/time.

Plasma clearance (CLp) for valdecoxib is about 6 l/hr.

Distribution Valdecoxibs fordelingsvolumen efter i. v. administration er ca.55 liter.

Distribution The volume of distribution of valdecoxib after its IV administration is approximately 55 litres.

Andre lægemidlers virkning på parecoxibs (eller dets aktive substans valdecoxibs) farmakokinetik

Effects of other medicinal products on the pharmacokinetics of parecoxib (or its active metabolite valdecoxib)

Valdecoxibs steady state plasmakoncentrationer nås inden for 4 dage ved dosering 2 gange dagligt.

Steady state plasma concentrations of valdecoxib were reached within 4 days with twice daily dosing.

Diurese eller alkalisering af urinen er muligvis ikke effektiv på grund af valdecoxibs høje proteinbinding.

Diuresis or alkalisation of urine may not be useful due to high protein binding of valdecoxib.

Valdecoxibs eliminationshalveringstid (t½) efter i. v. eller i. m. dosering af parecoxibnatrium er ca.8 timer.

After IV or IM dosing of parecoxib sodium, the elimination half-life (t1/2) of valdecoxib is about 8 hours.

Andre lægemidlers virkning på parecoxibs (eller dets aktive substans valdecoxibs) farmakokinetik18 Parecoxib hydrolyseres hurtigt til den aktive substans valdecoxib.

Effects of other medicinal products on the pharmacokinetics of parecoxib (or its active metabolite valdecoxib) Parecoxib is rapidly hydrolysed to the active metabolite valdecoxib.

Andre lægemidlers virkning på parecoxibs (eller dets aktive substans valdecoxibs) farmakokinetik Parecoxib hydrolyseres hurtigt til den aktive substans valdecoxib.
http://www.emea.europa.eu/

Effects of other medicinal products on the pharmacokinetics of parecoxib (or its active metabolite valdecoxib) Parecoxib is rapidly hydrolysed to the active metabolite valdecoxib.
http://www.emea.europa.eu/

Loratadine SibutramineGatifloxacin Nimesulide COX-2-Inhibitors:Celecoxib, Parecoxib, Valdecoxib,

Domperidone Clozapine Calcium folinate Ranitidine Isotretinoin Lisinopril Calcium 500/1000 Calcium 500 + Vitamin D 400 IU Calcium 500 + Vitamin D 200 IU Pravastatin Simvastatin Calcitonins Human coagulation factor VIII Loratadine Sibutramine Gatifloxacin Nimesulide COX-2-Inhibitors:

Valdecoxib Pharmacia Europe EEIG valdecoxib Part B

· Valdecoxib Pharmacia Europe EEIG · valdecoxib

Valdyn valdecoxib Part B

· Bextra · valdecoxib · Part B· Valdyn · valdecoxib · Part B

-oplysningerne om valdecoxib og parecoxib i CABG -(koronararterie-bypass

-the data on valdecoxib and parecoxib presented in the CABG (Coronary Artery Bypass

Kudeq valdecoxib Part B

· Part B· Kudeq · valdecoxib · Part B

Valdecoxib-Pfizer Europe EEIG valdecoxib Part B

· Valdecoxib-Pfizer Europe EEIG · valdecoxib

Valdecoxib fjernes ikke ved hæmodialyse.
http://www.emea.europa.eu/

Valdecoxib is not removed by haemodialysis.
http://www.emea.europa.eu/

Valdecoxib, men ikke parecoxib, fordeles i stor udstrækning til erytrocytterne.
http://www.emea.europa.eu/

Valdecoxib, but not parecoxib, is extensively partitioned into erythrocytes.
http://www.emea.europa.eu/

Elimination Valdecoxib udskilles via levermetabolisme, og mindre end 5% uomdannet valdecoxib genfindes i urinen.
http://www.emea.europa.eu/

Elimination Valdecoxib is eliminated via hepatic metabolism with less than 5% unchanged valdecoxib recovered in the urine.
http://www.emea.europa.eu/

- oplysningerne om valdecoxib og parecoxib i CABG - (koronararterie- bypass
http://www.emea.europa.eu/

- the data on valdecoxib and parecoxib presented in the CABG (Coronary Artery Bypass Graft) and
http://www.emea.europa.eu/

Det vides ikke, om valdecoxib udskilles i modermælken hos mennesker.
http://www.emea.europa.eu/

It is not known whether valdecoxib is excreted in human milk.
http://www.emea.europa.eu/

Det betyder, at stoffet omdannes til valdecoxib i kroppen.
http://www.emea.europa.eu/

This means that it is converted to valdecoxib in the body.
http://www.emea.europa.eu/