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7 cladribine is a prodrug which is taken up rapidly in cells after parenteral administration, and is phosphorylated intracellularly to the active nucleotide 2-chlorodeoxyadenosine-5'-triphosphate (cdatp) by deoxycytidine kinase (dck).
7 rakuline resistentsus ja tundlikkus kladribiin on eelravim, mis parenteraalse manustamise järgselt jõuab kiiresti rakkudesse ja mis ensüüm deoksütsütidiin kinaasi (dck) poolt fosforüülitakse intratsellulaarselt aktiivseks nukleotiidiks 2- kloordeoksüadenosiin- 5 ’ - trifosfaadiks (cdatp).
Last Update: 2011-10-23
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