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catechols and other drugs metabolised by catechol-o-methyltransferase (comt):
katecholaminai ir kiti vaistai, kurie metabolizuojami dalyvaujant katechol-o metiltransferazei (komt) .
Last Update: 2012-04-11
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a natural protein (enzyme) in your body, the (comt) catechol-o-methyltransferase breaks down the levodopa. .
natūralus jūsų organizmo baltymas (fermentas) katechol-o-metiltransferazė (komt) skaldo vaistą levodopą.
Last Update: 2017-04-26
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tolcapone is an orally active, selective and reversible catechol-o-methyltransferase (comt) inhibitor.
tolkaponas islieka aktyvus j geriant, yra selektyvus ir grztamo poveikio katechol-0-metiltransferazs (komt) inhibitorius.
Last Update: 2008-03-04
Usage Frequency: 2
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increases in liver enzymes were reported in studies with nitrocatechol inhibitors of catechol-o- methyltransferase (comt).
kepenų fermentų aktyvumo padidėjimas buvo užregistruotas tyrimų su katechol-o-metiltransferazės (komt) nitrokatecholo inhibitoriais metu.
Last Update: 2017-04-26
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the two major metabolic pathways are decarboxylation by dopa decarboxylase (ddc) and o-methylation by catechol-o-methyltransferase (comt).
du pagrindiniai medžiagų apykaitos keliai yra dekarboksilinimas veikiant dopos dekarboksilazei (ddk) ir o-metilinimas veikiant katechol-o-metiltransferazei (komt).
Last Update: 2017-04-26
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47 catechol-o-methyltransferase (comt) is a natural enzyme in your body that breaks down the levodopa medication used to treat your parkinson’ s disease.
katechol- 0- metiltransferazė (komt) yra natūralus jūsų organizmo fermentas, skaldantis vaistą levodopą, kuris vartojamas parkinsono ligai gydyti.
Last Update: 2012-04-11
Usage Frequency: 4
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entacapone belongs to a new therapeutic class, catechol-o-methyl transferase (comt) inhibitors.
entakaponas priklauso naujai vaistų klasei – katechol-o-metiltransferazės (komt) inhibitoriams.
Last Update: 2017-04-26
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levodopa is extensively metabolised to various metabolites, decarboxylation by dopa decarboxylase (ddc) and o-methylation by catechol-o-methyltransferase (comt) being the most important pathways.
levodopa ekstensyviai metabolizuojama vairius metabolitus, jos dekarboksilinimas veikiant dopadekarboksilazei (ddk) ir o-metilinimas veikiant katechol-o -metiltransferazei (komt) yra svarbiausi metabolizmo bdai.
Last Update: 2008-03-04
Usage Frequency: 3
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entacapone blocks an enzyme that is involved in the breakdown of levodopa in the body called catechol-o-methyl transferase (comt).
entakaponas blokuoja levodopą skaidantį fermentą katechol-o-metiltransferazę (komt).
Last Update: 2017-04-26
Usage Frequency: 1
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patients were not allowed to receive supplemental levodopa/carbidopa or catechol-o-methyl transferase (comt) inhibitor medicinal products during the trial.
tyrimo metu pacientams nebuvo leidžiama papildomai vartoti levodopos ir karbidopos arba katechol-o-metiltransferazės (komt) inhibitorių.
Last Update: 2017-04-26
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opicapone is a peripheral, selective and reversible catechol-o-methyltransferase (comt) inhibitor endowed with a high binding affinity (sub-picomolar) that translates into a slow complex dissociation rate constant and a long duration of action (>24 hours) in vivo.
opikaponas yra periferinis, selektyvus ir grįžtamas katechol-o-metiltransferazės (komt) inhibitorius, kuriam būdingas didelis afinitetas (subpikomolarinis), virstantis į pastovaus ir ilgo veikimo (> 24 valandų) lėtai disocijuojančius kompleksus in vivo.
Last Update: 2017-04-26
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tolcapone blocks an enzyme that is involved in the breakdown of levodopa in the body called catechol-o-methyl transferase (comt) .as a result, levodopa remains active for longer.
todl levodopa ilgesn laik islieka veiksminga ir tai palengvina parkinsono ligos pozymius ir simptomus, pvz., judesi sultjim ir pasunkjim.
Last Update: 2008-03-04
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with inhibition of the decarboxylase by a ddc inhibitor, catechol-o-methyltransferase (comt) becomes the major peripheral metabolic pathway catalyzing the conversion of levodopa to 3-o- methyldopa (3-omd), a potentially harmful metabolite of levodopa.
kai ddk inhibitorius nuslopina dekarboksilazę, katechol-o-metiltransferazė (komt) tampa pagrindiniu periferinio metabolizmo būdu, katalizuojančiu levodopos virsmą į 3-o-metildopą (3- omd), potencialiai žalingą levodopos metabolitą.
Last Update: 2017-04-26
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when patients are initially converted from immediate release levodopa/ddc inhibitor plus catechol-o- methyl transferase (comt) inhibitors (such as entacapone) to numient the dosing conversion guidelines provided in table 2 are recommended for initial dosing.
kai pacientai pirmą kartą pereina nuo greito veikimo levodopos ir ddk inhibitoriaus su katechol-o- metiltransferazės (komt) inhibitoriais (pvz., entakaponu) prie numient, pradinei dozei nustatyti rekomenduojama vadovautis 2 lentelėje pateiktomis dozės perskaičiavimo gairėmis.
Last Update: 2017-04-26
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both carbidopa and entacapone block some of the enzymes that are involved in the breakdown of levodopa in the body: carbidopa blocks the enzyme dopa decarboxylase, and entacapone blocks the enzyme catechol-o-methyl transferase (comt).
ir karbidopa, ir entakaponas blokuoja kai kuriuos fermentus, kurie dalyvauja skylant levodopai: karbidopa blokuoja fermentą dopadekarboksilazę, o entakaponas – fermentą katechol-o-metiltranferazę.
Last Update: 2017-04-26
Usage Frequency: 1
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thus, entacapone should be administered cautiously to patients being treated with medicinal products metabolised by catechol-o-methyl transferase (comt) , e. g. rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine, alpha-methyldopa, and apomorphine (see also section 4.5) .
todl entakapon atsargiai skirti pacientams, gydomiems vaistais, kuriuos metabolizuoja katechol-o-metiltransferaz (komt) , pvz., rimiteroliu, izoprenalinu, adrenalinu, dopaminu, dobutaminu, alfa-metildopa ir apomorfinu (zr.4. 5 skyri) .
Last Update: 2008-03-04
Usage Frequency: 1
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