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this protein is called topoisomerase i.
Šis baltymas vadinamas topoizomeraze i.
Last Update: 2012-04-11
Usage Frequency: 2
Quality:
antineoplastic effect: inhibition of topoisomerase ii.
antineoplastinis poveikis: topoizomerazs ii inhibicija.
Last Update: 2008-03-04
Usage Frequency: 1
Quality:
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these effects can be attributed to inhibition of topoisomerase ii.
toks poveikis gali būti susijęs su topoizomerazės ii slopinimu.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
the primary targets for pradofloxacin are the bacterial dna gyrase and topoisomerase iv enzymes.
pagrindiniai pradofloksacino taikiniai yra bakterijų fermentai – dnr girazė ir topoizomerazė iv.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
it blocks an enzyme called topoisomerase i, which is involved in the division of dna.
jis slopina fermentą topoizomerazę i, dalyvaujantį dnr replikacijoje.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
irinotecan belongs to a group of cancer medicines called ‘topoisomerase inhibitors’.
irinotekanas priklauso vaistų nuo vėžio grupei, vadinamai „topoizomerazės inhibitoriais“.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
resistance to levofloxacin is most often acquired through a stepwise process by target site mutations in dna gyrase and topoisomerase iv.
atsparumas levofloksacinui dažniausiai atsiranda dėl laipsniškų dnr girazės ir topoizomerazės iv poveikio vietų mutacijų.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
it blocks an enzyme called topoisomerase i, which is involved in copying cell dna, which is needed to make new cells.
Ši medžiaga slopina fermentą, vadinamą topoizomeraze i, kuris dalyvauja kopijuojant ląstelių dnr (to reikia, kad galėtų pasigaminti naujos ląstelės).
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
reversible association between pradofloxacin and dna gyrase or dna topoisomerase iv in the target bacteria results in inhibition of these enzymes and rapid death of the bacterial cell.
Įvykus grįžtamam pradofloksacino ir dnr girazės ar topoizomerazės iv susijungimui jautrioje bakterijoje, šie fermentai nuslopinami ir sukeliama greita bakterinės ląstelės žūtis.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
31 inhibition of topoisomerase-i by topotecan is the induction of protein-associated dna single-strand breaks.
topoizomeraz-i slopinant topotekanu, lstelje suzadinamas su baltymu susijusios dnr viengubos grandins nutrkimas.
Last Update: 2008-03-04
Usage Frequency: 1
Quality:
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topotecan inhibits topoisomerase-i by stabilising the covalent complex of enzyme and strand-cleaved dna which is an intermediate of the catalytic mechanism.
topoizomerazės-i slopinimas priklauso nuo to, kad topotekanas stabilizuoja šio fermento ir nutrauktos dnr grandinės kovalentinį kompleksą, kuris yra katalitinio mechanizmo tarpinė grandis.
Last Update: 2017-04-26
Usage Frequency: 5
Quality:
the cellular sequela of inhibition of topoisomerase-i by topotecan is the induction of protein-associated dna single-strand breaks.
topoizomerazės-i slopinimo topotekanu pasekmė ląstelėje yra su baltymu susijusios dnr viengubos grandinės nutrūkimo indukcija.
Last Update: 2017-04-26
Usage Frequency: 3
Quality:
topotecan inhibits topoisomerase-i by stabilising the covalent complex of enzyme and strand-cleaved dna which is an intermediate of the catalytic mechanism.the cellular sequela of
topotekanas slopina topoizomeraz-i, stabilizuodamas sio fermento ir nutrauktos dnr grandins kovalentin kompleks, kuris yra katalizinio mechanizmo tarpin grandis.
Last Update: 2008-03-04
Usage Frequency: 1
Quality:
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by blocking two enzymes called ‘dna gyrase’ and ‘topoisomerase iv’, pradofloxacin stops the bacteria from growing and multiplying.
blokuodamas du fermentus, vadinamus dnr giraze ir topoizomeraze iv, pradofloksacinas neleidžia bakterijoms augti ir daugintis.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
19 the anti-tumour activity of topotecan involves the inhibition of topoisomerase-i, an enzyme intimately involved in dna replication as it relieves the torsional strain introduced ahead of the moving replication fork.
topoizomerazė- i yra fermentas, artimai susijęs su dnr replikacija, kadangi mažina sukimosi įtampos jėgą, atsirandančią 19 priešais judančią replikacijos šakutę.
Last Update: 2012-04-11
Usage Frequency: 4
Quality:
the way it works is not entirely clear, but may be linked to the way the medicine attaches to iron in the body to form a ‘chelate’ and to its effect on some enzymes, such as topoisomerase ii.
jos veikimo mechanizmas nėra visiškai aiškus, tačiau galėtų būti susijęs su tuo, kaip vaistas jungiasi prie organizme esančios geležies sudarydamas chelatą, ir kaip veikia kai kuriuos fermentus, pvz., topoizomerazę ii.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
as a fluoroquinolone antibacterial agent, the bactericidal action of ciprofloxacin results from the inhibition of both type ii topoisomerase (dna-gyrase) and topoisomerase iv, required for bacterial dna replication, transcription, repair and recombination.
kaip antibakteriniu poveikiu pasižyminčio fluorochinolono, ciprofloksacino baktericidinis veikimas pasireiškia dėl to, kad yra slopinamos tiek ii tipo topoizomerazė (dnr- girazė), tiek topoizomerazė iv, kurios yra reikalingos bakterijų dnr replikacijai, transkripcijai, atstatymui ir rekombinacijai.
Last Update: 2012-04-11
Usage Frequency: 4
Quality: