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biotransformation seven major metabolites were identified and the metabolic pathways were identified as glucuronidation at the pyridine nitrogen, pyridinenoxidation with and without 3'hydroxylation on the indane ring, 3'hydroxylation of indane, phydroxylation of phenylmethyl moiety, and n depyridomethylation with and without the 3'hydroxylation.
biotransformação identificaram-se 7 metabolitos principais e as vias metabólicas foram identificadas como glucuronização no azoto piridínico, oxidação-n-piridínica com e sem hidroxilação-3'no anel indano, hidroxilação-3'do indano, hidroxilação-p do radical de fenilmetilo e depiridometilação-n com e sem hidroxilação-3 '.
Last Update: 2008-03-04
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