Results for extra medullary leukemic envolv... translation from English to Slovenian

in single and repeated dose toxicity studies in rats, the main findings were reduced body weight gain, haematological changes, reduced serum alkaline phosphatase and microscopic findings in the bone marrow (depletion of haematopoietic cells, fibrosis), spleen (secondary extra-medullary haematopoiesis) and bone (depletion of osteocytes, osteoblasts, osteoclasts, fibro-osseous lesions, disruption/disorganisation of the physis/growth line).
glavni izsledki v študijah toksičnosti po enkratnem in večkratnem odmerjanju pri podganah so bili manjše pridobivanje telesne mase, hematološke spremembe, zmanjšanje vrednosti serumske alkalne fosfataze in mikroskopske spremembe v kostnem mozgu (zmanjšanje števila krvotvornih celic, fibroza), vranici (sekundarna ekstra-medularna hematopoeza) in kosteh (zmanjšanje števila osteocitov, osteoblastov, osteoklastov, fibro-osealne lezije, prekinitev/destrukcija rastne plošče/rastne linije).