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QUADRAMET has an affinity for skeletal tissue and concentrates in areas of bone turnover in intimate association with hydroxyapatite; studies in rats have demonstrated that QUADRAMET is cleared rapidly from the blood and localises to growing areas of bone matrix, specifically the layer of osteoid undergoing mineralisation.
http://www.emea.europa.eu/

QUADRAMET muestra afinidad por el tejido óseo y se concentra en las zonas de recambio óseo, asociado íntimamente a la hidroxiapatita; los estudios realizados en ratas han puesto de manifiesto que QUADRAMET es aclarado rápidamente de la sangre y se localiza en las zonas de crecimiento de la matriz ósea, más concretamente, en la capa de la sustancia osteoide que sufre mineralización.
http://www.emea.europa.eu/

Last Update: 2012-04-10
Subject: Pharmaceuticals
Usage Frequency: 2
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There was no evidence of a mineralising defect, no aberrant accumulation of osteoid, and no woven bone in treated animals.

En los animales tratados no se hallaron evidencias de un defecto de mineralización, ni de una acumulación anormal de osteoide ni de hueso dañado.

Last Update: 2008-03-04
Subject: Medical
Usage Frequency: 1
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