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dies führt zu einem verstärkten bedarf an cholesterol in den leberzellen, was eine zweifache wirkung auslöst: einmal die steigerung der transkription und aktivität des cholesterolbiosyntheseenzyms hydroxymethylglutarylcoenzym a (hmg-coa) - reduktase und auf der anderen seite die steigerung der anzahl der hepatischen low-density- lipoprotein-rezeptoren.
this causes an increased demand for cholesterol in the liver cells, resulting in the dual effects of increasing transcription and activity of the cholesterol biosynthetic enzyme, hydroxymethyl-glutaryl-coenzyme a (hmg-coa) reductase, and increasing the number of hepatic low-density lipoprotein receptors.
Last Update: 2012-04-10
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