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in klinischen studien veränderte lasofoxifen den metabolismus von dextromethorphan (cyp2d6-substrat) und chlorzoxazon (cyp2e1-substrat) oder die pharmakokinetik von warfarin (cyp2c9-substrat), methylprednisolon (cyp3a4-substrat) oder digoxin (mdr1 p-glykoproteinsubstrat) nicht.
in clinical studies, lasofoxifene did not alter the metabolism of dextromethorphan (cyp2d6 substrate) and chlorzoxazone (cyp2e1 substrate) or the pharmacokinetics of warfarin (cyp2c9 substrate), methylprednisolone (cyp3a4 substrate) or digoxin (mdr1 p-glycoprotein substrate).
Last Update: 2012-04-10
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