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Die blutgerinnungshemmenden Eigenschaften von Desirudin zeigen sich in dessen Fähigkeit, die Gerinnungszeit von menschlichem Plasma oder Rattenplasma zu verlängern, unabhängig davon, ob dies direkt (Thrombinzeit) oder intrinsisch (aPTT) oder extrinsisch (PT) induziert wird.
http://www.emea.europa.eu/

The anticoagulant properties of desirudin are demonstrated by its ability to prolong the clotting time of human or rat plasma whether induced directly (thrombin time) or via the intrinsic (aPTT) or extrinsic (PT) pathways.
http://www.emea.europa.eu/

Last Update: 2012-04-10
Subject: Pharmaceuticals
Usage Frequency: 2
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In-vitro-Studien haben darüber hinaus gezeigt, dass Bivalirudin die aktivierte partielle Thromboplastinzeit (aPTT) , die Thrombinzeit (TT) und die Prothrombinzeit (PT) des normalen Humanplasmas konzentrationsabhängig verlängert.Darüber hinaus ließ sich durch Bivalirudin mit Serum von Patienten, bei denen es in der Vergangenheit zu heparininduzierter Thrombozytopenie/heparininduziertem Thrombose-Syndrom (HIT/HITTS) gekommen war, keine Thrombozyten-Aggregationsreaktion induzieren.

In vitro studies have also shown that bivalirudin prolongs the activated partial thromboplastin time (aPTT) thrombin time (TT) and pro-thrombin time (PT) of normal human plasma in a concentration-dependent manner and that bivalirudin does not induce a platelet aggregation response against sera from patients with a history of Heparin-Induced Thrombocytopenia/Thrombosis Syndrome (HIT/HITTS) .

Last Update: 2008-03-04
Subject: Medical
Usage Frequency: 1
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