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6 alfa-idrossipaclitaxel e 3’-para-diidrossipaclitaxel.
3’-para-dihydroxypaclitaxel, respectively.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
il 6 alfa-idrossipaclitaxel è il componente predominante rinvenuto nelle feci.
6 alpha-hydroxypaclitaxel is the major component excreted in faeces.
Last Update: 2012-04-12
Usage Frequency: 4
Quality:
6 alfa-idrossipaclitaxel, 3’-para- idrossipaclitaxel e 6 alfa, 3’-para-diidrossipaclitaxel.
6 alpha-hydroxypaclitaxel, 3’-para-hydroxypaclitaxel and 6 alpha, 3’-para-dihydroxypaclitaxel.
Last Update: 2017-04-26
Usage Frequency: 5
Quality:
studi in vitro hanno mostrato che cyp2c8 e 3a4 sono coinvolti rispettivamente nella formazione di 6 alfa-idrossipaclitaxel e 3'-para-diidrossipaclitaxel.
in vitro studies have shown that cyp2c8 and 3a4 are involved in the formation of 6 alpha-hydroxypaclitaxel and 3'-para-dihydroxypaclitaxel, respectively.
Last Update: 2012-04-12
Usage Frequency: 2
Quality:
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i dati farmacocinetici emersi dagli studi bo15935 e m77004 condotti su donne affette da mbc her2 positivo hanno suggerito che l'esposizione a paclitaxel e doxorubicina (e ai loro metaboliti principali 6-α- idrossipaclitaxel, poh e doxorubicinolo, dol) non veniva alterata in presenza di trastuzumab (dose di carico da 8 mg/kg o 4 mg/kg ev seguita da 6 mg/kg ogni 3 settimane o 2 mg/kg settimanalmente ev, rispettivamente).
pharmacokinetic data from studies bo15935 and m77004 in women with her2-positive mbc suggested that exposure to paclitaxel and doxorubicin (and their major metabolites 6-α hydroxyl- paclitaxel, poh, and doxorubicinol, dol) was not altered in the presence of trastuzumab (8 mg/kg or 4 mg/kg iv loading dose followed by 6 mg/kg q3w or 2 mg/kg q1w iv, respectively).
Last Update: 2017-04-26
Usage Frequency: 1
Quality: