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As análises radiocromatográficas, antes e depois da hidrólise por β- glucuronidase, indicam que todos os metabolitos estavam na forma de glucuronatos conjugados, à excepção do amfenac.
http://www.emea.europa.eu/

Radiochromatographic analyses before and after β -glucuronidase hydrolysis indicated that all metabolites were in the form of glucuronide conjugates, with the exception of amfenac.
http://www.emea.europa.eu/

Last Update: 2012-04-12
Subject: Pharmaceuticals
Usage Frequency: 1
Quality:

As propriedades farmacocinéticas do oseltamivir, tais como a reduzida ligação às proteínas e o metabolismo independente dos sistemas de metabolização com intervenção do CYP450 e da glucuronidase (ver secção 5. 2), sugerem que é improvável a ocorrência de interacções medicamentosas clinicamente relevantes, por estes mecanismos.
http://www.emea.europa.eu/

Pharmacokinetic properties of oseltamivir, such as low protein binding and metabolism independent of the CYP450 and glucuronidase systems (see section 5.2), suggest that clinically significant drug interactions via these mechanisms are unlikely.
http://www.emea.europa.eu/

Last Update: 2012-04-12
Subject: Pharmaceuticals
Usage Frequency: 1
Quality:

As propriedades farmacocinéticas do oseltamivir, tais como a reduzida ligação às proteínas e o metabolismo independente dos sistemas de metabolização com intervenção do CYP450 e da glucuronidase (ver secção 5. 2) , sugerem que é improvável a ocorrência de interacções medicamentosas clinicamente relevantes, por estes mecanismos.

Pharmacokinetic properties of oseltamivir, such as low protein binding and metabolism independent of the CYP450 and glucuronidase systems (see section 5.2) , suggest that clinically significant drug interactions via these mechanisms are unlikely.

Last Update: 2008-03-04
Subject: Medical
Usage Frequency: 4
Quality:
Warning: This alignment may be wrong.
Please delete it you feel so.

As análises radiocromatográficas, antes e depois da hidrólise por6 -glucuronidase, indicam que todos os metabolitos estavam na forma de glucuronatos conjugados, à excepção do amfenac.

Radiochromatographic analyses before and after -glucuronidase hydrolysis indicated that all metabolites were in the form of glucuronide conjugates, with the exception of amfenac.

Last Update: 2008-03-04
Subject: Medical
Usage Frequency: 1
Quality:
Warning: This alignment may be wrong.
Please delete it you feel so.

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