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cyp 3a4 sa podieľa na klírense kortizolu tvorbou 6β-hydroxykortizolu, ktorý sa vylučuje močom.
cyp 3a4 is involved in the clearance of cortisol by the formation of 6β-hydroxycortisol which is excreted in urine.
Last Update: 2017-04-26
Usage Frequency: 1
Quality:
maravirok neovplyvňoval klinicky významne farmakokinetiku midazolamu, perorálnych antikonceptív etinylestradiolu a levonorgestrelu, či pomer 6β-hydroxykortizolu/kortizolu v moči, čo svedčí proti inhibícii alebo indukcii cyp3a4 in vivo.
maraviroc had no clinically relevant effect on the pharmacokinetics of midazolam, the oral contraceptives ethinylestradiol and levonorgestrel, or urinary 6β-hydroxycortisol/cortisol ratio, suggesting no inhibition or induction of cyp3a4 in vivo.
Last Update: 2017-04-26
Usage Frequency: 3
Quality: