Predhodna ocena porazdelitvenega koeficienta

Preliminary estimate of the partition coefficient

predhodno oceno porazdelitvenega koeficienta (glej zgoraj),

the preliminary assessment of the partition coefficient (see above),

določitev porazdelitvenega koeficienta je treba opraviti z zelo čistimi analitskimi reagenti.

The determination of the partition coefficient should be carried out with high purity analytical grade reagent.

Za določitev porazdelitvenega koeficienta je treba določiti koncentracijo preskusne snovi v obeh fazah.

For the determination of the partition coefficient, it is necessary to determine the concentrations of the test substance in both phases.

Pred izvedbo katerega koli postopka, je treba pridobiti predhodno oceno porazdelitvenega koeficienta.

Before carrying out either of the experimental procedures a preliminary estimate of the partition coefficient should first be obtained.

Disociacija ali asociacija raztopljenih molekul lahko povzroči odstopanje od Nernstovega porazdelitvenega zakona.

Dissociation or association of the dissolved molecules result in deviations from the Nernst Partition Law.

Izkušnje so pokazale, da 50 takšnih obratov običajno zadostuje za vzpostavitev porazdelitvenega ravnotežja.

Experience has shown that 50 such rotations are usually sufficient for the establishment of the partition equilibrium.

Vrednost porazdelitvenega koeficienta se lahko oceni na podlagi topnosti preskusne snovi v čistih topilih:

The value of the partition coefficient can be estimated by the use of the solubilities of the test substance in the pure solvents:

Če karkoli kaže na odvisnost porazdelitvenega koeficienta od koncentracije, je to treba vključiti v poročilo,

If there is a suggestion of concentration dependency of the partition coefficient, this should be noted in the report,

Preden se ta osnovna raztopina uporabi za določanje porazdelitvenega koeficienta, je treba natančno določiti njeno koncentracijo.

The concentration of this stock solution should be precisely determined before it is employed in the determination of the partition coefficient.

Porazdelitvenega volumna ni mogoče določiti, ker se absorbira le neznatna količina učinkovine in ker sistemska farmakokinetika ni opredeljena.
http://www.emea.europa.eu/

The volume of distribution cannot be determined because the active substance is minimally absorbed and has no defined systemic pharmacokinetics.
http://www.emea.europa.eu/

Določene vrednosti porazdelitvenega koeficienta, izražene kot logaritmi z osnovo 10, morajo biti v območju ± 0,3 log enot.

The determined values of the partition coefficient expressed as their common logarithms should fall within a range of ± 0,3 log units.

Pri bolnikih z revmatoidnim artritisom niso opažali večje odvisnosti očistka in porazdelitvenega volumna zdravila od starosti ali telesne mase.
http://www.emea.europa.eu/

No major age- or weight-related differences in clearance or volume of distribution were observed in rheumatoid arthritis patients.
http://www.emea.europa.eu/

Začetni razpolovni čas je minutnega reda, končni razpolovni čas je reda nekaj ur, z možno prisotnostjo globokega porazdelitvenega prostora..
http://www.emea.europa.eu/

The initial half-life is in the order of minutes and the terminal half-life is several hours, with the possible presence of a deep compartment.
http://www.emea.europa.eu/

Porazdelitev Porazdelitvenega volumna ni mogoče določiti, ker se absorbira le neznatna količina zdravila, in ker nima opredeljene sistemske farmakokinetike.
http://www.emea.europa.eu/

Distribution The volume of distribution cannot be determined because the drug is minimally absorbed and has no defined systemic pharmacokinetics.
http://www.emea.europa.eu/

izračunane vrednosti porazdelitvenega koeficienta (P) in njihova srednja vrednost za vsak sklop preskusnih pogojev ter srednja vrednost vseh določitev.

the calculated values of the partition coefficient (P) and the mean should be reported for each set of test conditions as should the mean for all determinations.

Analiza populacijske farmakokinetike pri odraslih bolnikih in pri starostnikih ni pokazala nikakršne klinično pomembne odvisnosti očistka in porazdelitvenega volumna od telesne mase.
http://www.emea.europa.eu/

Population pharmacokinetic analysis of adult and elderly patients showed no clinically relevant relationship of clearance and volume of distribution with body weight.
http://www.emea.europa.eu/

Porazdelitev Mediana vrednost porazdelitvenega volumna v končni fazi (Vz) po enkratni intravenski injekciji zdravila bolnikom s psoriazo je bila od 57 do 83 ml/ kg.
http://www.emea.europa.eu/

Distribution Median volume of distribution during the terminal phase (Vz) following a single intravenous administration to patients with psoriasis ranged from 57 to 83 ml/ kg.
http://www.emea.europa.eu/

fizikalnih in kemijskih lastnosti snovi, zlasti tališča, vrelišča, parnega tlaka, površinske napetosti, topnosti v vodi in porazdelitvenega koeficienta n-oktanol/voda;

physico-chemical properties of the substance, in particular melting point, boiling point, vapour pressure, surface tension, water solubility, partition coefficient n-octanol/water;

Za določitev porazdelitvenega koeficienta je treba vzpostaviti ravnotežje med vsemi medsebojno delujočimi komponentami sistema in določiti koncentraciji snovi, raztopljene v dveh fazah.

In order to determine a partition coefficient, equilibrium between all interacting components of the system must be achieved, and the concentrations of the substances dissolved in the two phases must be determined.