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Función de los leucocitos polimorfonucleares

Polymorphonuclear Leukocyte Function.

Last Update: 2014-04-05
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PMN, leucocitos polimorfonucleares (neutrófilos).

PMNs, Polymorphonuclear leukocytes (neutrophils).

Last Update: 2014-04-05
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PMN, leucocitos polimorfonucleares; LPS, lipopolisacárido.

PMNs, Polymorphonuclear leukocytes; LPS, lipopolysaccharide.

Last Update: 2014-04-05
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PMN, leucocitos polimorfonucleares; LPS, lipopolisacáridos.

PMNs, Polymorphonuclear leukocytes; LPS, lipopolysaccharide.

Last Update: 2014-04-05
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Los neutrófilos o leucocitos polimorfonucleares (PMN), predominan en las primeras etapas de la inflamación gingival para fagocitar y matar las bacterias de la placa.

Neutrophils, or polymorphonuclear leukocytes (PMNs), predominate in the early stages of gingival inflammation to phagocytose and kill plaque bacteria.

Last Update: 2014-04-05
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Conforme se rompe la vesícula o la ampolla, la lesión ulcerada se infiltra con leucocitos polimorfonucleares (PMN) y la superficie puede mostrar supuración.

As the vesicle or bulla ruptures, the ulcerated lesion becomes infiltrated with polymorphonuclear leukocytes (PMNs), and the surface may show suppuration.

Last Update: 2014-04-05
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Se ha demostrado la acumulación de la pirlimicina en células polimorfonucleares; sin embargo, no se ha podido demostrar la destrucción intracelular del Staphylococcus aureus.
http://www.emea.europa.eu/

Pirlimycin has been shown to accumulate in polymorphonuclear cells, however, intracellular killing of Staphylococcus aureus was not demonstrated.
http://www.emea.europa.eu/

Last Update: 2012-04-10
Subject: Pharmaceuticals
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El aumento de la vasopermeabilidad permite la exudación de plasma que contiene albúminas, globulinas, fibrinógeno y, la extravasación de los leucocitos (principalmente leucocitos polimorfonucleares) a través del endotelio y la membrana basal de los vasos sanguíneos en el tejido del sitio infectado.

The increase in vasopermeability allows the exudation of plasma containing albumins, globulins, and fibrinogen, and the extravasation of leukocytes (mainly polymorphonuclear leukocytes) through the endothelium and basement membrane of the blood vessel into the tissue at the infected site.

Last Update: 2014-04-09
Subject: Medical
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Los efectos negativos del tabaquismo en la cicatrización de una herida quirúrgica pueden estar relacionados con los efectos celulares perjudiciales de la nicotina (Raulin y colaboradores, 1988.) o su sub producto, la cotinina (McGuire y colaboradores., 1989), sobre los fibroblastos y los leucocitos polimorfonucleares (Kenney y colaboradores., 1977).

The adverse impact of smoking on the healing surgical wound may relate to the deleterious cellular effects of nicotine (Raulin et al., 1988) or its by-product, cotinine (McGuire et al., 1989), and on fibroblasts and polymorphonuclear leukocytes (Kenney et al., 1977).

Last Update: 2014-04-05
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Estudios que investigaron la histología (con microscopio óptico y ultraestructurales) de tejidos sanos e inflamados que rodean implantes en humanos han indicado que la respuesta inflamatoria a la placa es similar a la observada en los tejidos periodontales.87 Las células polimorfonucleares y mononucleares transmigran de manera normal a través del epitelio del surco peri-implante (Figura 68-24).87

Studies investigating the histology (light microscopic and ultrastructural) of healthy and inflamed tissues surrounding implants in humans have indicated that the inflammatory response to plaque is similar to that observed in periodontal tissues.87 Polymorphonuclear cells and mononuclear cells transmigrate normally through the periimplant sulcular epithelium (Figure 68-24).87

Last Update: 2014-04-05
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Después de 4 días de acumulación de placa, los vasos sanguíneos inmediatamente adyacentes al epitelio de unión se distienden y contienen leucocitos polimorfonucleares (PMN, neutrófilos).

After 4 days of plaque accumulation, the blood vessels immediately adjacent to the junctional epithelium are distended and contain polymorphonuclear leukocytes (PMNs, neutrophils).

Last Update: 2014-04-05
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Los leucocitos polímorfonucleares (PMN) que abandonaron los vasos sanguíneos en respuesta a estímulos quimiotácticos de los componentes de la placa viajan al epitelio, cruzan la lámina basal, aparecen en el epitelio y emergen en el área de la bolsa (Véase la Figura 7-3).

PMNs that have left the blood vessels in response to chemotactic stimuli from plaque components travel to the epithelium, cross the basement lamina, and are found in the epithelium, emerging in the pocket area (see Figure 7-3).

Last Update: 2014-04-05
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Además de células epiteliales descamadas, la saliva contiene toda clase de leucocitos, de los que los polimorfonucleares (PMN) son las células principales.

In addition to desquamated epithelial cells, the saliva contains all forms of leukocytes, of which the principal cells are PMNs.

Last Update: 2014-04-05
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Las fuentes de las colagenasas pueden ser los fibroblastos o leucocitos polimorfonucleares (PMN neutrófilos),87 o también pueden ser secretadas por bacterias.35 Las fosfolipasas son enzimas lisosomales y citoplásmicas, pero también son producidas por microorganismos.15 La mayoría de los elementos del GCF detectados hasta el momento han sido enzimas, pero también hay sustancias no enzimáticas.

The source for collagenases may be fibroblasts or polymorphonuclear leukocytes (PMNs, neutrophils),87 or collagenases may be secreted by bacteria.35 Phospholipases are lysosomal and cytoplasmic enzymes but are also produced by microorganisms.15 The majority of GCF elements detected thus far have been enzymes, but there are nonenzymatic substances as well.

Last Update: 2014-04-05
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Inmediatamente después de realizar la sutura (hasta 24 horas) se establece una conexión entre el colgajo y el diente o superficie ósea por medio de un coágulo de sangre, que es un retículo de fibrina con muchos leucocitos polimorfonucleares, eritrocitos, residuos de células lesionadas y capilares en el borde de la herida.3 También hay bacterias y un exudado o trasudado como resultado de la lesión al tejido.

Immediately after suturing (up to 24 hours), a connection between the flap and the tooth or bone surface is established by a blood clot, which consists of a fibrin reticulum with many polymorphonuclear leukocytes, erythrocytes, debris of injured cells, and capillaries at the edge of the wound.3 Bacteria and an exudate or transudate also result from tissue injury.

Last Update: 2014-04-05
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También hay hemorragia en los tejidos con capilares dilatados y aparecen leucocitos polimorfonucleares (PMN) abundantes poco después en la superficie de la herida.

Hemorrhage is also present in the tissues with dilated capillaries and abundant polymorphonuclear leukocytes (PMNs), which appear on the wound surface.

Last Update: 2014-04-05
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Los MMP predominantes en la periodontitis, sobre todo la MMP-8 y MMP-9, se derivan de los leucocitos polimorfonucleares (PMN) 30 y son demasiado electivos para degradar el colágeno tipo 1, el cual es el más abundante en la encía y en el ligamento periodontal.52 Se ha mostrado que los niveles de MMP tipo PMN aumentan con la gravedad de la enfermedad periodontal y disminuyen después del tratamiento.24,30 La liberación de grandes cantidades de MMP en el periodonto lleva a una alteración anatómica significativa y degradación de los tejidos conjuntivos, lo que contribuye a los signos clínicos de periodontitis.

The predominant MMPs in periodontitis, particularly MMP-8 and MMP-9, derive from PMNs30 and are extremely effective in degrading type I collagen, the most abundant collagen type in gingiva and periodontal ligament.52 Levels of PMN-type MMPs have been shown to increase with severity of periodontal disease and decrease after therapy.24,30 The release of large quantities of MMPs in the periodontium leads to significant anatomic disruption and breakdown of the connective tissues, contributing to the clinical signs of periodontitis.

Last Update: 2014-04-05
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De hecho, se han identificado defectos en la función de los leucocitos polimorfonucleares (PMN, neutrófilos) en algunos pacientes con periodontitis agresiva.34,36 Además, en un número pequeño de casos, se puede identificar una enfermedad sistémica como la neutropenia, que explica de manera clara la gravedad inusual de la enfermedad periodontal para ese sujeto.14,15 Sin embargo, en la mayoría de los pacientes con periodontitis agresiva, no se pueden identificar las enfermedades o trastornos sistémicos.

Indeed, defects in polymorphonuclear leukocyte (PMN, neutrophil) function have been identified in some patients with aggressive periodontitis.34,36 Also, in a small number of cases, a systemic disease, such as neutropenia, can be identified that clearly explains the unusual severity of the periodontal disease for that individual.14,15 In most patients with aggressive periodontitis, however, systemic diseases or disorders cannot be identified.

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En algunos de estos casos, esto se encuentra relacionado con enfermedades sistémicas específicas que afectan el sistema inmunológico, por ejemplo, neutropenia, disfunción de leucocitos polimorfonucleares y diabetes.

In a few of these cases, this is related to specific systemic diseases that affect the immune system, e.g., neutropenia, polymorphonuclear leukocyte dysfunction, and diabetes.

Last Update: 2014-04-05
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Por tanto, se ha reconocido que la edad tiene mucho menos efecto en la modificación de la respuesta del huésped de lo que se pensaba anteriormente.20,27 Es posible demostrar diferencias entre individuos jóvenes y ancianos en cuanto a las células T y B, las citoquinas y las células asesinas naturales, pero no en las células polimorfonucleares y la actividad de macrófagos.

As a result, age has been recognized as having much less effect in altering the host response than previously thought.20,27 Differences between young and older individuals can be demonstrated for T and B cells, cytokines, and natural killer cells but not for polymorphonuclear cells and macrophage activity.

Last Update: 2014-04-05
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